Research Objective:

Mechanisms of Epithelial Injury In Canine INFLAMMATORY BOWEL DISEASE - IBD

Principal Investigator:

Peter J. Felsburg, VMD, PhD
University of Pennsylvania

Abstract: Inflammatory bowel disease (IBD) occurs frequently in dogs and can cause vomiting, diarrhea, anorexia, and weight loss. Despite the incidence and severity of IBD in dogs, the underlying causes remain uncertain. Current theory suggests an interplay of genetic, environmental, and immunological factors. Investigators will obtain epithelial cells from gastrointestinal tract tissue during routine endoscopy in dogs with IBD. They will study these cells to determine their involvement in the inflammatory response of the gut. Results obtained should shed light on this disease and may lead to more specific strategies for treating and preventing IBD.