Research Objective:

Reciprocal Relationship of PTEN and p21 in Canine Cancer

Principal Investigator:

Jaime F. Modiano, VMD, Ph.D.
University of Colorado-Denver

Abstract:

An estimated one out of every two dogs alive today will get cancer in its lifetime, and as many as 50 percent of those will die from the disease. Despite significant gains in cancer treatment, a thorough understanding of why cancers arise and why they behave as they do is essential to improving prevention and treatment. For this project, researchers |will investigate two proteins whose interactions appear to be intimately tied to the behavior of two serious cancers, melanoma and hemangiosarcoma. What they learn may help to test targeted therapies for these cancers and significantly  improve the lives of affected dogs.