Research Objective:

The goal of this study is to determine whether oral administration of the antihistamine hydroxyzine is absorbed into the dog's bloodstream and metabolized sufficiently to suppress allergic reactions. The results will help determine the optimal dose and frequency of this drug for treating atopic dermatitis in dogs. 

Principal Investigator:

Dr. Thierry Olivry
North Caroline State University

Abstract:

Skin allergies are a common reason for veterinary visits. Atopic dermatitis, a chronic skin disease, is a lifelong condition that affects the quality of life for affected dogs and can even alter their relationships with their owners. It is often treated with antihistamines, but little is known about the absorption and distribution of these drugs in dogs. This lack of knowledge can lead to dogs receiving inappropriate dosages of the drug or incorrect frequency, causing treatment to fail. In addition, some of these drugs can cause adverse side effects. The goal of this study is to determine whether oral administration of the antihistamine hydroxyzine is absorbed into the dog's bloodstream and metabolized sufficiently to suppress allergic reactions. The results will help determine the optimal dose and frequency of this drug for treating atopic dermatitis in dogs.

Meet the Investigator: Dr. Olivry is a professor at North Carolina State University and an adjunct clinical associate professor of dermatology at the University of North Carolina. He received his veterinary degree from the University of Toulouse, France, and his Ph.D. in comparative pathology from the University of California-Davis.