AKC Canine Health Foundation Grant #2273

Research Objective:

Preclinical detection of hypoadrenocorticism (Addison's disease) in dogs: Development and evaluation of laboratory techniques for the diagnosis of immune-mediated canine adrenal disease

Principal Investigator:

M. Rick Med Vet.
Animal Health Diagnostic Laboratory
Michigan State University, East Lansing

Abstract:

The adrenals are hormone producing glands located near each kidney. Their products are of such importance that, without them, an individual cannot survive. If the adrenals are damaged and not able to make sufficient hormones, a potentially life-threatening disease called hypoadrenocorticism arises. This disease is known as Addison's disease. Both humans and dogs can be affected. It is most often caused by an immune reaction in which the body's own defense mechanisms destroy the adrenals. This process releases telltale antibodies into the circulation before severe damage occurs. We hope to be able to measure these antibodies in serum. With this test, we will be able to make an early diagnosis long before affected animals become ill. Such a test will also help us identify which breeds, families and ages are most at risk for this disease. With this information we can identify which individual animals require close monitoring for the development of the disease and what breeding strategies might help eradicate it.