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Research Update CHF 03045-A MY1: Artificial Intelligence and Machine Learning for Diagnosis of Dog Sperm Morphology

Collection of all semen samples required for the study has been completed. Samples from 62 dogs presented to the veterinary hospital at The Ohio State University have been preserved in formalin and shipped to the University of Pennsylvania. Acquisition of dog sperm images has started. In addition, we have started the work with our collaborators at the University of Wisconsin‐Madison to develop an algorithm to automatically identify and crop sperm using a bank of bovine sperm images. Continue reading “Research Update CHF 03045-A MY1: Artificial Intelligence and Machine Learning for Diagnosis of Dog Sperm Morphology”

Research Update CHF EY3 02686-A: Pattern of Thyroid Function Tests during Recovery from Acute Nonthyroidal Illness

Excerpt from EY3 of Dr. Bolton’s work.

An enunciation of the relationship between thyroid hormones and thyroid stimulating hormone during acute nonthyroidal illness and recovery will be postponed until after the statistical analysis is complete .

Total T4 is the most common hormone measured in dogs suspected of hypothyroidism and is low in cases of this disease. It can also decrease in dogs with nonthyroidal illness, frequently resulting in an inappropriate diagnosis of hypothyroidism and unnecessary thyroid hormone supplementation. Continue reading “Research Update CHF EY3 02686-A: Pattern of Thyroid Function Tests during Recovery from Acute Nonthyroidal Illness”

Research Update CHF 02519 Final: Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangiosarcomas Within and Between Geographic Locations

We gained substantial and seemingly important information relative to the aims of this study. We were able to obtain the initial set of samples on April 26, 2018 so we had a short delay in starting this study. Subsequently, the COVID epidemic and loss of research personal resulted in repeated interruptions in our research efforts. After completing all Year I study aims, we continued to work on improvements in immunohistochemistry and FISH localization of Bartonella organisms within various cell types. Continue reading “Research Update CHF 02519 Final: Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangiosarcomas Within and Between Geographic Locations”

Research Update CHF 02723 MY3: Scientific and Clinical Assessment of Fecal Microbiota Transplant in Obese Dogs: SLIM Study

We screened (comprehensive physical examinations, bloodwork, and fecal analysis) 51 dogs for the SLIM study. Of these, 31 met the inclusion criteria and were enrolled. Of these enrolled dogs, 25 dogs completed the 24-week clinical trial. Unfortunately, 6 dogs were removed from the study early with the most common reason related to administration of antimicrobials needed for underlying health conditions including dog bite wounds, urinary tract infections, and surgical procedures. Based on recalculating our power analysis for sample size estimation, out current samples size (n=25) is sufficient to find a significant difference in weight loss between the treatment groups. Our last SLIM patient finished the clinical trial at the end of October 2022. Since this time, we have entered the analysis phase and sample processing for microbiome sequencing and metabolomics. Continue reading “Research Update CHF 02723 MY3: Scientific and Clinical Assessment of Fecal Microbiota Transplant in Obese Dogs: SLIM Study”

Research Update CHF 02758 FINAL: Optical Coherence Tomography for Margin Evaluation of Canine Skin and Subcutaneous Neoplasms

Thank you for supporting our project titled “Optical coherence tomography for margin evaluation of skin and subcutaneous neoplasms”. This project is investigating an emerging diagnostic imaging tool, optical coherence tomography that uses light waves to generate real time high-resolution images of tissues for detection of residual cancer cells immediately following surgical removal. Our team involves collaboration between veterinary medicine and pathology at the Ohio State University. We have completed enrollment of the 80 cases. We completed the first phase of this project where we are looking at imaging skin tumors after surgical removal in dogs. Continue reading “Research Update CHF 02758 FINAL: Optical Coherence Tomography for Margin Evaluation of Canine Skin and Subcutaneous Neoplasms”

Research Update CHF 02624 Final: Embracing Polygenicity of Common Complex Disease in Dogs: Genome-wide Association of Cruciate Ligament Rupture

We have now completed recruitment and marker genotyping of Labrador Retriever dogs under this award. A final single nucleotide polymorphism (SNP) marker data set of 1,006 dogs has been assembled and filtered for data analysis, slightly exceeding what was promised under the award. We have now completed analysis of these data to estimate heritability of cruciate ligament rupture, determined the extent of the polygenicity of the disease, and developed a genetic testing method for accurately predicting risk of cruciate ligament rupture. Continue reading “Research Update CHF 02624 Final: Embracing Polygenicity of Common Complex Disease in Dogs: Genome-wide Association of Cruciate Ligament Rupture”

Research Update 02945-MOU MY2: Understanding the genetic basis of Addison’s disease in Portuguese Water Dogs

Over the 1.5 years of this study, we have focused primarily on sample collection and running an initial set of genetics experiments. We collected samples mostly through PWD-related channels working directly with our collaborators in the PWDF/PWDCA. Continue reading “Research Update 02945-MOU MY2: Understanding the genetic basis of Addison’s disease in Portuguese Water Dogs”

Research Update CHF 02783 MY3: Transcriptional Profiling of Canine Soft Tissue Sarcoma

Soft tissue sarcoma (STS) encompasses a number of neoplasms that are derived from mesenchymal cells including fibrosarcoma, myxosarcoma, hemangiopericytoma, and undifferentiated sarcoma. In the dog, STSs arise frequently in the dermis/subcutis and represent up to 15% of the neoplasms in this location. Our primary aim of this grant was to collect cases of canine STS for histologic and gene expression analysis. Continue reading “Research Update CHF 02783 MY3: Transcriptional Profiling of Canine Soft Tissue Sarcoma”

Research Update CHF 02780 MY3: Bladder Carcinogen Exposures in Pet Dogs

Bladder cancer case recruitment has been steady through our alliance with Antech, which is attaching our study flyer to all BRAF urine tests that are positive for bladder cancer. We are now enrolling 2-3 dogs with bladder cancer per month. We also have a list of possible matched controls through our expanded outreach through Facebook. We have recorded questionnaire data encoded for all dog kits that have been returned to us. Continue reading “Research Update CHF 02780 MY3: Bladder Carcinogen Exposures in Pet Dogs”