Latest News

Research Update CHF 02403-MOU EY-4: Microphthalmia and Delayed Growth Syndrome in the Portuguese Water Dog

The objective of this study is to A) clinicopathologically and molecularly characterize microphthalmia with delayed growth in the Portuguese Water Dog (POWD) and B) develop a DNA-based test to assist breeders with their breeding programs and avoid producing affected dogs. Continue reading “Research Update CHF 02403-MOU EY-4: Microphthalmia and Delayed Growth Syndrome in the Portuguese Water Dog”

Research Update CHF 02819 EY1: Identification of Bartonella henselae In Vivo Induced Antigens for Development of a Reliable Serodiagnostic Assay for Canine Bartonelloses

During the past 4 years, with support from the American Kennel Club Canine Health Foundation, our research group has documented that current serological assays lack sensitivity, specificity, or both for assessing exposure to Bartonella spp. in dogs. Thus, when used diagnostically for an individual dog or epidemiologically for the detection of Bartonella spp. antibodies in dog populations, results would be inaccurate due to false-negative (poor sensitivity) or false positive (poor specificity) IFA testing. Continue reading “Research Update CHF 02819 EY1: Identification of Bartonella henselae In Vivo Induced Antigens for Development of a Reliable Serodiagnostic Assay for Canine Bartonelloses”

Research Update CHF 02806-MOU MY2: Strategic Prevention of Canine Hemangiosarcoma: Lifetime Follow-Up

The goal of this project is to develop a reliable, accessible, and actionable test to identify dogs at risk for hemangiosarcoma during the earliest stages of the disease and to use a strategic, rationally designed approach to prevent its occurrence in these high-risk dogs before it becomes clinically detrimental and life-threatening. Continue reading “Research Update CHF 02806-MOU MY2: Strategic Prevention of Canine Hemangiosarcoma: Lifetime Follow-Up”

Research Update CHF 02686-A EY2: Pattern of Thyroid Function Tests during Recovery from Acute Nonthyroidal Illness

To date, 52 cases have been screened for possible study enrollment, of which 13 fulfilled enrollment criteria (~50% of total cases needed). Based on the case enrollment thus far, 11/13 dogs had normalization of total T4 by the 2-week recheck. Continue reading “Research Update CHF 02686-A EY2: Pattern of Thyroid Function Tests during Recovery from Acute Nonthyroidal Illness”

Research Update CHF 02624 Mid-year 3: Embracing Polygenicity of Common Complex Disease in Dogs: Genome-wide Association of Cruciate Ligament Rupture

We have met our Labrador Retriever recruitment for this study over the past year months. We will continue to complete DNA isolation and marker genotyping of the remaining dogs needed for the study as long as the genotyping service remains open under the Covid-19 pandemic. Public engagement with the project continues to be good. Continue reading “Research Update CHF 02624 Mid-year 3: Embracing Polygenicity of Common Complex Disease in Dogs: Genome-wide Association of Cruciate Ligament Rupture”

Research Update CHF 02528 Final: Developing a Next Generation Sequencing Diagnostic Platform for Tick-Borne Diseases

Diagnostic tests based on the detection of DNA from harmful organisms in clinical samples have revolutionized veterinary medicine in the last decades. Currently, diagnostic panels for several
vector-borne diseases (VBDs) are available through universities and private labs in the USA and abroad. However, the vast majority of results from sick dogs are negative, which frustrates veterinarians and dog owners trying to reach a definitive diagnosis. Continue reading “Research Update CHF 02528 Final: Developing a Next Generation Sequencing Diagnostic Platform for Tick-Borne Diseases”

Research Update 02945-MOU MY1: Understanding the genetic basis of Addison’s disease in Portuguese Water Dogs

Over the first 6 months of this study, we have focused primarily on sample collection. We collected samples mostly through PWD-related channels working directly with our collaborators in the PWDF/PWDCA. We also attended the PWD National Specialty in September 2021 to promote the study and collect samples, and we established a collaboration with Dr. Anita Oberbauer at UC Davis to share samples that she had already collected. Continue reading “Research Update 02945-MOU MY1: Understanding the genetic basis of Addison’s disease in Portuguese Water Dogs”

Research Update CHF 02643-A Final: Examination of the Effects of Cannabidiol on Canine Neoplastic Cell Apoptosis/Autophagy and Potential for Chemotherapy Resistance or Sensitivity

The objective of the project was to examine the effects of CBD on canine cancer cell growth proliferation with aims towards understanding the signaling pathways involved and the apoptotic response related to CBD. A second aim was to understand the influence of CBD co-treatment with chemotherapeutics such as doxorubicin and vincristine. Continue reading “Research Update CHF 02643-A Final: Examination of the Effects of Cannabidiol on Canine Neoplastic Cell Apoptosis/Autophagy and Potential for Chemotherapy Resistance or Sensitivity”

Research Update CHF 02692-A Final: Diagnostic Accuracy of Point of Care Analysis of Canine Urine and Plasma in Marijuana Toxicosis

Between February 2019 and March 2020, 56 dogs were enrolled in the study. The amount of Δ9- tetrohydrocannabinol (THC) ingested was available for eight dogs (14%). The average dose ingested for those dogs was 175 mg (range 35-4,400). Types of sources reported included both commercial and homemade edible products (15), marijuana plant material (3), and commercial THC concentrate (1). Continue reading “Research Update CHF 02692-A Final: Diagnostic Accuracy of Point of Care Analysis of Canine Urine and Plasma in Marijuana Toxicosis”

Research Update CHF 02553 Final: Targeted Next Generation Sequencing Panel for Comprehensive Testing of Vector-borne Pathogens

We developed a comprehensive method for detecting infectious diseases in dogs, taking the guesswork out of determining which tests to use for diagnosis, and potentially improving disease surveillance because of the comprehensive nature of the test. The method is a targeted next-generation sequencing (NGS) assay, which takes advantage of the amount of data that can be generated with NGS but also includes a PCR step prior to sequencing. This reduces costs associated with the sequencing and provides adequate turn-around time for diagnostic use. Continue reading “Research Update CHF 02553 Final: Targeted Next Generation Sequencing Panel for Comprehensive Testing of Vector-borne Pathogens”