Research Update CHF 02783 EY1: Transcriptional Profiling of Canine Soft Tissue Sarcoma

Soft tissue sarcoma (STS) encompasses a number of neoplasms that are derived from mesenchymal cells including fibrosarcoma, myxosarcoma, hemangiopericytoma, and undifferentiated sarcoma. In the dog, STSs arise frequently in the dermis/subcutis and represent up to 15% of the neoplasms in this location. Our primary aim of this grant was to collect cases of canine STS for histologic and gene expression analysis.

We originally had planned to collect both fresh-frozen and paraffin-embedded samples. Due to the temporary closure of our veterinary hospital, we were unable to procure fresh frozen samples; however, since the start date of year 1 of the grant, I have collected 100 canine patient STS samples. We have performed RNA extraction in these cases and are currently working to analyze the data from these first 100 cases.

End-year 1 update from Dr. Miller

End-Year-1 Research Update Dr. Miller for more accurate prognosis in soft tissue sarcoma.