Research
Whole-genome Sequencing of non-prcd PRA in PWD
Continue readingThe Portuguese Water Dog Foundation will contribute $9,400 for Whole Genome Sequencing (WGS) on 4 different dogs [2 affected, 1 carriers, and 1 homozygous normal]. Samples will be tested at the WGS platform at the University of Bern, Switzerland. Dr. Aguirre’s eye lab is part of a consortium at Bern
Genetic and Environmental Risk for Lymphoma in Boxer Dogs
Continue readingLymphoma is a fatal cancer of the blood cells that can occur in any dog. Lymphoma is more common in Boxers, Golden Retrievers, and several other purebreds, which suggests involvement of inherited genes. Recent research has focused on gene mutations in the tumors of dogs with lymphoma. However, we do
The Role of Complex Translocations Associated with TP53 Somatic Mutations for Aiding Prognosis of Canine Diffuse Large B cell Lymphoma
Continue readingLymphoma accounts for up to 24% of all cancers diagnosed in pet dogs. Among these cases diffuse large B-cell lymphoma (DLBCL) is the most common subtype. Despite continued advances in veterinary medicine, the response to treatment for canine lymphoma remains highly variable with no reliable means to predict response. Studies
Broad-Range Detection of Canine Tick-Borne Disease and Improved Diagnostics Using Next-Generation Sequencing
Continue readingDiagnostic tests based on the detection of DNA of infectious organisms from clinical samples have revolutionized veterinary medicine in the last decades. Currently, diagnostic panels for several tickborne organisms are available through universities and private laboratories in the USA and abroad. However, the vast majority of results from clinically ill
Disease Risks Associated with Spay and Neuter: A Breed-Specific, Gender Specific
Continue readingThis study extends the investigator’s recently completed AKC Canine Health Foundation-funded project studying 12 dog breeds to identify major differences in the degree to which spay or neuter may be related to an increase in joint disorders (hip dysplasia; cranial cruciate ligament tear) and/or cancers (lymphoma; hemangiosarcoma; and mast cell
Identification of Genetic Risk Factors for Canine Epilepsy
Continue readingEpilepsy is one of the most common neurologic diseases of dogs and a top concern of dog breeders. Despite strong evidence that genetics is important in determining the risk of idiopathic epilepsy, numerous gene mapping studies have failed to identify a locus that accounts for that risk in either dogs
Investigating a Ketogenic Medium-Chain Triglyceride (MCT) Supplement for the Treatment of Drug-Resistant Canine Idiopathic Epilepsy and Its Behavioral Comorbidities
Continue readingCanine epilepsy is a chronic neurological condition, often requiring lifelong medication with antiepileptic drugs (AEDs). Despite appropriate treatment with available AEDs, seizure freedom may not always be achievable. Indeed, over two thirds of dogs with epilepsy continue to have seizures long-term and around 20-30% remain poorly controlled on standard AEDs.
Veterinary Oncology Fellowship-University of Missouri
Continue readingShirley Chu, DVM; University of Missouri Dr. Chu of the University of Missouri College of Veterinary Medicine is a veterinary oncology resident and graduate student pursuing her PhD. Dr. Jeffrey Bryan serves as Dr. Chu’s mentor for her project on “Examination of the Methylome of Golden Retriever B cell lymphoma”.
Capturing Tumor Cells in Canine Blood
Continue readingThis pilot study’s aim is to develop a blood assay to count tumor cells circulating in a dog’s blood. This technique has proven effective in telling the clinician how aggressive a cancer is and provide information as to treatment and outcome for the patient. This assay is available for humans
A Novel Approach for Prevention of Canine Hemangiosarcoma
Continue readingHemangiosarcoma, an aggressive form of cancer in dogs, is the cause of death for one out of every five Golden Retrievers in the United States. Portuguese Water Dogs and Boxers also have an especially high risk for this disease which is devastating for all dogs. Hemangiosarcoma is incurable partly because