Research

  • Determining the Correct Dosing for a Novel Drug to Treat Canine Lymphoma

    This study will determine the best dose for dogs with lymphoma, and researchers will study how well AD 198 affects cancer cells.

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  • Potential Drug Therapy for Lymphoma

    Lymphoma is one of the most common and fatal cancers in dogs. Most dogs treated with chemotherapy go into remission, but the cancer quickly develops drug resistance and recurs. Chemotherapy generally works by initiating apoptosis, a normal process in which cells undergo programmed death. Apoptosis occurs throughout life and is

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  • Mechanistic Relationship of IL-8 in Cell Proliferation and Survival of Canine Hemangiosarcoma

    Characterize the direct effects of IL-8 on HSA cells. Results The hypothesis tested in this project was that interleukin-8 (IL-8) promotes growth and survival of hemangiosarcoma cells. This hypothesis was based on our previous results showing significant enrichment of IL-8 gene expression in hemangiosarcoma cells compared to normal endothelial cells

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  • Making Advanced Discoveries in Golden Cancers

    The three-year project will examine genetic traits that contribute to risk and progression of hemangiosarcoma and lymphoma. Golden Retrievers have been one of the most popular breeds in America for decades, but unfortunately these dogs also have one of the highest incidences of cancer. Hemangiosarcoma and lymphoma account for more

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  • Enrichment for Canine Cancer Stem Cells by In Vitro Manipulation and Chemotherapy

    This study will look at cancer stem cells to develop therapeutic strategies that target these cells and generate new, more effective treatment approaches with fewer side effects for dogs with cancer. Cancer therapy for dogs has become more common, but treatment doesn’t always lead to long-term remission, and some therapies

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  • Studying How Mast Cell Tumors Become Malignant

    Researchers will analyze expression of miRNAs associated with aggressive mast cell disease and begin to define how they may promote aggressive progression of tumors in dogs. Mast cell tumors are the most common skin tumor in dogs, and they are often fatal. Unfortunately, identifying the tumors likely to become malignant

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  • Determining Risk Factors for Lymphoma

    To determine whether dogs with genetic defects in an important detoxification enzyme, called GSTT, are more likely to develop lymphoma. Lymphoma, one of the most common cancers in dogs, is fatal in most patients. Though the underlying causes of the disease aren’t understood, exposure to industrial pollutants and commonly used

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  • Evaluating Drugs to Treat Hemangiosarcoma

    Tyrosine kinase inhibitors may have the potential to control the growth of hemangiosarcoma. Hemangiosarcoma remains one of the deadliest canine cancers. Despite treatments such as chemotherapy, immunotherapy and surgery, dogs rarely live beyond six months after diagnosis. New approaches are needed to improve the survival time of dogs afflicted with

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  • Investigating a Noninvasive, At-Home Diagnostic Technique for Gastrointestinal Disorders

    Gastrointestinal disorders are common in dogs and are often associated with a change in the rate food moves through the stomach and intestines. This study uses a noninvasive, wireless sensor capsule to determine the gastrointestinal transit in dogs. The information will help veterinarians to better diagnose gastrointestinal diseases, including bloat,

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  • Genetic Analysis of Hypoandrenocorticism in Nova Scotia Duck Tolling Retrievers

    Addison’s disease, also known as hypoadrenocorticism, is a deficiency of hormones that are produced by the adrenal glands and help regulate a dog’s metabolism, blood pressure, electrolyte balance and stress response. Though the disease is relatively uncommon in dogs, certain breeds—including Nova Scotia Duck Tolling Retrievers, Bearded Collies, Great Danes,

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