Research
Previously funded studies appear chronologically, with the most recent appearing first.
Gene Expression Profiling of Relapsed Lymphoma in Dogs
Lymphoma is one of the most common cancers in dogs. Breeds with a high incidence include Boxers, Golden Retrievers, and German Shepherds. It is also one of the most treatable cancers – more than 90 percent of dogs treated with chemotherapy go into remission. Unfortunately, most dogs relapse and eventually die from the disease. Results […]Continue readingReceptor Tyrosine Kinase Activity in Canine Hemangiosarcoma
Hemangiosarcoma (HSA) is a common and fatal canine cancer, for which there are no effective treatments. HSA is caused by malignant blood vessel cells that spread. Despite surgery and chemotherapy, the median survival time for dogs diagnosed with HSA is little more than six months. It is more commonly seen in male dogs between eight […]Continue readingRecombinant Thyrotropin (TSH)
Standard for the Next Generation of Canine TSH Immunoassays With Improved Sensitivity Overall, this research project completed the genetic phase of the project and are reproducibly producing reasonable quantities of recombinant canine TSH in vitro and purifying it with high recovery to high purity. In the future, this standard can serve as a reproducible standard […]Continue readingEstablishing a Genetic Linkage Between Addison’s Disease and DNA Markers
Statistical evaluation of the dogs’ pedigrees suggests a single locus of large Addison’s disease is a late onset disorder caused by deterioration of the adrenal gland cortex. Although Addison’s disease occurs in the general canine population, some breeds show a greater prevalence as noted by owners and breeders: Bearded Collies, Standard Poodles, Leonbergers, Portuguese Water […]Continue readingprcd Progressive Retinal Atrophy
Progressive Retinal Atrophy (PRA) is an inherited eye disease that cause blindness in dogs. In Portuguese Water Dogs, it is a form of PRA called prcd or progressive rod-cone degeneration and is inherited through an autosomal recessive gene. Because the disease can be passed on only if both dogs carry the gene, a test that […]Continue readingPreclinical Detection of Hypoadrenocorticism (Addison’s Disease) in Dogs
Development and Evaluation of Laboratory Techniques for the Diagnosis of Immune-Mediated Canine Adrenal Disease Addison’s disease in the dog has been well studied. It is very similar to the disease in humans. Signs include anorexia, vomiting, weakness, pain, diarrhea, lethargy, the inability to handle stress, and, in severe cases, cardiac arrest. Since there is no […]Continue readingCharacterizing the Inheritance of Addison’s Disease and Linked DNA Markers
Addison’s disease is a late onset disorder caused by the deterioration of the adrenal gland. Addison’s occurs in the domestic dog at approximately 0.1 percent, with some breeds showing a greater prevalence. Notably, the Bearded Collie, the West Highland White Terrier, the Standard Poodle, the Portuguese Water Dog, and the Leonberger are considered to have […]Continue readingGenotypic and Phenotypic Dissection of Canine Hip Dysplasia
A pedigree based on greyhounds and dysplastic Labrador Retrievers will be expanded to find genetic markers associated with the genetic mutations that cause hip dysplasia (HD). Several measures of the inherited traits of the dysplastic hip, age, distraction index, dorsolateral subluxation score and Orthopedic Foundation for Animals hip score, will be used to maximize the […]Continue reading
