Research

Previously funded studies appear chronologically, with the most recent appearing first.

  • Evaluation of a New Vaccine for Canine Brucellosis

    Canine infection by Brucella spp. constitutes a serious problem for dog breeders and pet owners, leading to the economic burden associated with reproductive loss and veterinary care. Canine brucellosis is also considered a public health concern because of its potential to be transmitted to humans. Within the US, the disease has reemerged due to the […]
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  • Identifying the Disease‐Defining Autoantibodies in Canine Addison’s Disease

    Addison’s disease is a common and life‐threatening disorder in dogs in which the body’s immune system destroys the outer layer of the adrenal glands. The adrenal glands produce hormones that are critical for energy metabolism, immune system function, intestinal health, and kidney function. Symptoms of Addison’s disease can mimic other conditions, and as a result, […]
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  • Microphthalmia and Delayed Growth Syndrome in the Portuguese Water Dog

    Microphthalmia and delayed growth syndrome (aka “puppy eye syndrome”) has been reported by Portuguese Water Dog breeders dating as far back as 1986. However, there is no information in the scientific literature and the majority of data concerning this syndrome has been obtained from records of breeders, which have anecdotal reports of the disease and […]
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  • Understanding the Relationship between Intestinal Bacteria and Inflammatory Bowel Disease (IBD)

    Scientific Title: Tackling the Canine Microbiome in Chronic Enteropathy: Characterizing the Functionally Significant Changes that Occur with Remission of Disease Summary: Researchers are looking at changes in gut bacteria that stimulate the immune system in dogs with inflammatory bowel disease to help identify novel ways to diagnose and treat this disease. Description: Inflammatory bowel disease […]
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  • Investigating Cancers and Exposure to Environmental Chemicals

    Scientific Title: Detoxification of Environmental Carcinogens by Glutathione-Stransferases in Dogs Summary: Researchers will find out how the dog’s body breaks down common environmental chemicals that have been linked to cancers in humans. Description: When dogs or humans are exposed to toxic chemicals in the environment, they use glutathione-S-transferase (GST) enzymes to break down and neutralize […]
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  • Identifying Cellular Mechanisms of Inflammation During Canine Tick-Borne Diseases

    Tick-borne diseases are found in all 50 states of the United States and are the most common vector-borne disease diagnosed in people in the US. The predominant disease is Lyme disease, caused by Borrelia burgdorferi and related species (sensu lato). Other important canine tick-borne diseases include those caused by Anaplasma platys, Anaplasma phagocytophilum (Anaplasmosis), Babesia […]
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  • Genome sequencing and antimicrobial susceptibilities of Escherichia coli isolated from clinical cases of canine pyometra

    Pyometra is a potentially life-threatening infection of the canine uterus by bacteria, most commonly Escherichia coli (E. coli). In humans with recurrent infections, E. coli produces biofilm, a layer of polysaccharide that protects the organism from the host immune system as well as antibiotic agents, decreasing treatment efficacy. Current treatments for pyometra are costly, time-consuming, […]
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  • Harnessing a Dog’s Own Immune System to Kill Lymphoma Tumor Cells

    Lymphoma is the most common malignancy of dogs representing up to 25% of diagnosed cancers. Dogs often develop an aggressive form of lymphoma that is rarely curable, with most unfortunately succumbing to disease within 12 months of diagnosis despite best available chemotherapies. Dr. Wilson will develop a new treatment to re-train the dog’s own immune […]
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  • Transcriptome Based Diagnostics in Canine Soft Tissue Sarcoma

    Sarcomas are malignant cancers that can arise in any part of the body; however, in the dog, a subset referred to as soft tissue sarcomas account for 10-15% of all skin and subcutaneous cancers. Traditionally biopsy and subsequent histology have been the primary means of diagnosing these cancers. The histology is assigned to one of […]
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  • Identification of genetic mutations in anal sac carcinoma in English Cocker Spaniels

    English Cocker Spaniels (ECSs) are about 7 times more likely than other dog breeds to develop anal sac carcinoma (ASC). Hence, there appears to be a genetic basis for this disease development in ECSs. The investigators will sequence the genomes and transcriptomes of blood and ASC tumor samples collected from ECS dogs across the US. […]
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