Research

Previously funded studies appear chronologically, with the most recent appearing first.

  • Searching for Ways to Control Hemangiosarcoma Cancer Cells in Dogs

    Hemangiosarcoma is a highly metastatic and incurable cancer that can affect dogs at any age. It is particularly prevalent in certain breeds such as Golden Retrievers, German Shepherds and Portuguese Water Dogs. Unfortunately, hemangiosarcoma is a disease that is poorly understood and for which there are currently no good treatment options. One of the main […]
    Continue reading
  • Plasma Cortisol Concentration in Dogs with Pituitary Dependent Hyperadrenocorticism and Atypical Cushing’s Syndrome

    To use a modified version of intermittent samplings to assess whether dogs with atypical Cushing’s syndrome produce increased cortisol over a certain time period. Results Twenty-eight dogs were enrolled in the study to compare cortisol concentrations among healthy dogs, dogs with excess cortisol associated with pituitary dependent Cushing’s syndrome and dogs categorized as having “atypical” […]
    Continue reading
  • Genetic Background and the Angiogenic Phenotype in Cancer

    This project will continue the researchers’ observations on gene appearance profiles in hemangiosarcoma from Golden Retrievers to German Shepherd Dogs and Portuguese Water Dogs, and it also will define how new targeted therapies may effectively control the disease in these and other dog breeds. Results Certain dog breeds are prone to develop certain types of […]
    Continue reading
  • Understanding the Role of Specific Cells in Spreading Lymphoma

    One of the limitations in identifying therapeutic targets for canine lymphoma has been the lack of reliable systems to study lymphoma cells in the laboratory. This study uses a culture system, developed by the principal investigator, to maintain lymphoma cells in the laboratory and study a protein that helps lymphoma spread. The findings may highlight […]
    Continue reading
  • Developing a New Treatment for Canine Lymphoma

    To develop a drug similar to Rituximab that works on canine lymphoma patients. Blood cell lymphomas affect about 30 dogs in every 100,000. Diffuse large B cell lymphoma (DLBCL) is a common type affecting dogs and is similar to non-Hodgkin’s lymphoma in humans. Current treatment induces remission in about 75 percent of patients but the […]
    Continue reading
  • Determining the Correct Dosing for a Novel Drug to Treat Canine Lymphoma

    This study will determine the best dose for dogs with lymphoma, and researchers will study how well AD 198 affects cancer cells.
    Continue reading
  • Potential Drug Therapy for Lymphoma

    Lymphoma is one of the most common and fatal cancers in dogs. Most dogs treated with chemotherapy go into remission, but the cancer quickly develops drug resistance and recurs. Chemotherapy generally works by initiating apoptosis, a normal process in which cells undergo programmed death. Apoptosis occurs throughout life and is critical for developing and maintaining […]
    Continue reading
  • Mechanistic Relationship of IL-8 in Cell Proliferation and Survival of Canine Hemangiosarcoma

    Characterize the direct effects of IL-8 on HSA cells. Results The hypothesis tested in this project was that interleukin-8 (IL-8) promotes growth and survival of hemangiosarcoma cells. This hypothesis was based on our previous results showing significant enrichment of IL-8 gene expression in hemangiosarcoma cells compared to normal endothelial cells isolated from non-malignant hematomas. Here, […]
    Continue reading
  • Making Advanced Discoveries in Golden Cancers

    The three-year project will examine genetic traits that contribute to risk and progression of hemangiosarcoma and lymphoma. Golden Retrievers have been one of the most popular breeds in America for decades, but unfortunately these dogs also have one of the highest incidences of cancer. Hemangiosarcoma and lymphoma account for more than 30 percent of the […]
    Continue reading
  • Enrichment for Canine Cancer Stem Cells by In Vitro Manipulation and Chemotherapy

    This study will look at cancer stem cells to develop therapeutic strategies that target these cells and generate new, more effective treatment approaches with fewer side effects for dogs with cancer. Cancer therapy for dogs has become more common, but treatment doesn’t always lead to long-term remission, and some therapies have debilitating side effects. A […]
    Continue reading