Research

Previously funded studies appear chronologically, with the most recent appearing first.

  • Making Advanced Discoveries in Golden Cancers

    The three-year project will examine genetic traits that contribute to risk and progression of hemangiosarcoma and lymphoma. Golden Retrievers have been one of the most popular breeds in America for decades, but unfortunately these dogs also have one of the highest incidences of cancer. Hemangiosarcoma and lymphoma account for more than 30 percent of the […]
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  • Enrichment for Canine Cancer Stem Cells by In Vitro Manipulation and Chemotherapy

    This study will look at cancer stem cells to develop therapeutic strategies that target these cells and generate new, more effective treatment approaches with fewer side effects for dogs with cancer. Cancer therapy for dogs has become more common, but treatment doesn’t always lead to long-term remission, and some therapies have debilitating side effects. A […]
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  • Studying How Mast Cell Tumors Become Malignant

    Researchers will analyze expression of miRNAs associated with aggressive mast cell disease and begin to define how they may promote aggressive progression of tumors in dogs. Mast cell tumors are the most common skin tumor in dogs, and they are often fatal. Unfortunately, identifying the tumors likely to become malignant is challenging because little is […]
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  • Determining Risk Factors for Lymphoma

    To determine whether dogs with genetic defects in an important detoxification enzyme, called GSTT, are more likely to develop lymphoma. Lymphoma, one of the most common cancers in dogs, is fatal in most patients. Though the underlying causes of the disease aren’t understood, exposure to industrial pollutants and commonly used herbicides may increase a dog’s […]
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  • Evaluating Drugs to Treat Hemangiosarcoma

    Tyrosine kinase inhibitors may have the potential to control the growth of hemangiosarcoma. Hemangiosarcoma remains one of the deadliest canine cancers. Despite treatments such as chemotherapy, immunotherapy and surgery, dogs rarely live beyond six months after diagnosis. New approaches are needed to improve the survival time of dogs afflicted with this devastating disease. This study […]
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  • Investigating a Noninvasive, At-Home Diagnostic Technique for Gastrointestinal Disorders

    Gastrointestinal disorders are common in dogs and are often associated with a change in the rate food moves through the stomach and intestines. This study uses a noninvasive, wireless sensor capsule to determine the gastrointestinal transit in dogs. The information will help veterinarians to better diagnose gastrointestinal diseases, including bloat, gastritis and inflammatory bowel disease, […]
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  • Genetic Analysis of Hypoandrenocorticism in Nova Scotia Duck Tolling Retrievers

    Addison’s disease, also known as hypoadrenocorticism, is a deficiency of hormones that are produced by the adrenal glands and help regulate a dog’s metabolism, blood pressure, electrolyte balance and stress response. Though the disease is relatively uncommon in dogs, certain breeds—including Nova Scotia Duck Tolling Retrievers, Bearded Collies, Great Danes, Leonbergers, Portuguese Water Dogs, Standard […]
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  • Assessing Therapeutic Targets for Adrenocortical Tumors

    This study is looking at new therapeutic targets for medical treatment of cortisol-secreting adrenocortical tumors, which cause Cushing’s disease, one of the most common canine endocrine disorders. Co-sponsored with the Morris Animal Foundation, Grant Number: D09CA-913 RESEARCHERS Dr. Miriam J. Kool, DVM University of Utrecht, The Netherlands
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  • Pharmakokinetics and Pharmacodynamics of Hydroxyzine in Healthy Dogs

    Atopic dermatitis is a common allergic skin disease in dogs and humans. Antihistamines are among the most commonly prescribed treatments. Unfortunately, the optimal dosages of commonly used antihistamines have never been scientifically determined, and their effects have not been validated in dogs. Researchers at North Carolina State University wanted to determine whether hydroxyzine, one of […]
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  • MicroRNA Profiling and MicroRNA-Based Treatment of Canine Cancers

    The goals of this study are to identify important canine miRNAs that can be used to improve cancer diagnosis and treatment in the dog. Results MicroRNAs (miRNAs) are small non-protein coding RNAs that have been implicated in humans as having a fundamental role in cancer initiation and progression. Osteosarcoma (OSA) is the most common bone […]
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