Research

Previously funded studies appear chronologically, with the most recent appearing first.

  • Pooled Association Mapping for Canine Hereditary Disorders

    To develop a system that will map genetic traits causing health problems. More than 450 canine genetic traits are listed on the Online Mendelian Inheritance in Animals list. These traits affect all body systems in dogs and can cause health problems ranging from mild disease susceptibility to severe illness and death. Researchers will use a […]
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  • MicroRNA Expression Profiling of Canine Osteosarcoma

    By studying miRNA expression in osteosarcoma, the investigators hope to identify new molecular targets for therapy that will lead to better treatment of this disease. Osteosarcoma, commonly known as bone cancer, is a significant cause of death in large- and giant-breed dogs. Because cancer is believed to be fundamentally a genetic disease, genomic approaches are […]
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  • Reciprocal Relationship of PTEN and p21 in Canine Cancer

    An estimated one out of every two dogs alive today will get cancer in its lifetime, and as many as 50 percent of those will die from the disease. Despite significant gains in cancer treatment, a thorough understanding of why cancers arise and why they behave as they do is essential to improving prevention and […]
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  • Enhance Detection, Diagnosis and Treatment of Canine Lymphoma

    A Collaborative Study by Veterinary Oncologists, Pathologists, and Diagnostic Laboratories to Enhance Detection, Diagnosis and Treatment of Canine Lymphoma To enhance detection, diagnosis and treatment of lymphoma. Therefore altering cost of treatment according to the type of tumor (as in humans) and increase survival rate. Results Canine lymphoma is the neoplasm most often treated by […]
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  • Juvenile Cardiomyopathy

    Our ultimate goal is to develop a mutation-based test for JDCM. There are several difficulties with JDCM, especially compared with other genetic diseases that affect your breed. Because the diagnosis of affected animals is often made after it is no longer possible to obtain blood or tissue, the most useful DNA samples cannot be obtained […]
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  • Comparison of 2 ACTH Stimulation Tests in Determining Adrenal Function in Critically Ill Dogs

    Use of low-dose ACTH stimulation testing may be important in diagnosing mild degrees of adrenocortical insufficiency and a new syndrome, critical illness-related corticosteroid insufficiency (formerly known as relative adrenal insufficiency), which has been recognized in critically ill human and veterinary patients. Both 0.5 and 5 μg/kg doses of cosyntropin cause maximal adrenal stimulation with regard […]
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  • Mapping Genes Associated with Canine Hemangiosarcoma

    Hemangiosarcoma (HSA), a malignant tumor of vascular endothelial cells, is a significant health concern in dogs, with an incidence of ~2% of all tumors. A national health survey of Golden Retriever reported that neoplasia accounted for >60% of all reported deaths and HAS was the most common malignant tumor affecting >15% of Golden Retrievers. A […]
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  • Identifying Genes Regulating Addison’s Disease in the Portuguese Water Dog

    Addison’s disease, or primary adrenocortical insufficiency, is characterized by destruction of the adrenal cortex, resulting in the inability to produce cortisone when stimulated with the hormone ACTH. In Portuguese Water Dogs (PWDs), this disease occurs with a frequency of 1-2 percent, and is a heritable autoimmune disease of low penetrance, caused by several interacting genes. […]
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  • Mapping Refinement of Quantitative Trait Loci for Canine Hip Dysplasia

    Hip dysplasia is one of the most common inherited traits in dogs with an extremely high incidence in some large breeds. It is caused by mutations in multiple genes. In previous studies, investigators discovered the genetic markers that point to the chromosomal regions that harbor the genes that contribute to hip dysplasia. In this study, […]
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  • Mechanism of Epithelial Injury in Canine Inflammatory Bowel Disease

    Inflammatory bowel disease (IBD) occurs relatively frequently in dogs and can cause vomiting, diarrhea, anorexia and weight loss. Despite the incidence and severity of IBD in dogs, the underlying causes remain uncertain. Current theory suggests an interplay of genetic, environmental and immunological factors. Investigators will obtain epithelial cells from gastrointestinal tract tissue during routine gastrointestinal […]
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