Soft tissue sarcoma (STS) encompasses a number of neoplasms that are derived from mesenchymal cells including fibrosarcoma, myxosarcoma, hemangiopericytoma, and undifferentiated sarcoma. In the dog, STSs arise frequently in the dermis/subcutis and represent up to 15% of the neoplasms in this location. Our primary aim of this grant was to collect cases of canine STS for histologic and gene expression analysis. Continue reading “Research Update CHF 02783 MY3: Transcriptional Profiling of Canine Soft Tissue Sarcoma”
Research Update CHF 02780 MY3: Bladder Carcinogen Exposures in Pet Dogs
Bladder cancer case recruitment has been steady through our alliance with Antech, which is attaching our study flyer to all BRAF urine tests that are positive for bladder cancer. We are now enrolling 2-3 dogs with bladder cancer per month. We also have a list of possible matched controls through our expanded outreach through Facebook. We have recorded questionnaire data encoded for all dog kits that have been returned to us. Continue reading “Research Update CHF 02780 MY3: Bladder Carcinogen Exposures in Pet Dogs”
Research Update CHF 02772 FINAL: Identifying Early Stage Ultra-rare Mutations as Predictive Biomarkers of Lymphoma in High-risk versus Low-risk Breeds Within the Dog Aging Project
The primary goal of this project is to test the hypothesis that breeds vary in risk of lymphoma due, at least in part, to breed-specific variation in rates of mutation in genes relevant to lymphoma. To test this hypotheses, we needed to gather blood samples from breeds at high risk and low risk of lymphoma, and from individuals of different ages within those breeds. We would then measure the frequency of rare mutations in several genes, and ask if this frequency is higher in breeds at relatively high risk of lymphoma. Continue reading “Research Update CHF 02772 FINAL: Identifying Early Stage Ultra-rare Mutations as Predictive Biomarkers of Lymphoma in High-risk versus Low-risk Breeds Within the Dog Aging Project”
Research Update CHF 02534 EY 3 Update: Clinical Trial for Evaluation of Propranolol and Doxorubicin in the Treatment of Canine Hemangiosarcoma
We opened the trial on July 1, 2019. As of June 27, 2021, we have enrolled 18 dogs in the study and no dose limiting toxicities within the initial 21-day assessment period have been observed. Based on these results, we are continuing to enroll dogs at the highest dose of propranolol (1.3 mg/kg) being tested.
Propranolol and doxorubicin levels in the blood from all of the dogs enrolled to date have been analyzed. Continue reading “Research Update CHF 02534 EY 3 Update: Clinical Trial for Evaluation of Propranolol and Doxorubicin in the Treatment of Canine Hemangiosarcoma”
Research Update Final 02309-T: Targeting the Cancer Epigenome: The Effect of Specific Histone Lysine Methyltransferase Inhibition in Canine B-Cell Lymphoma
Lymphoma, particularly the large, B-cell subtype, is one of the most common malignancies in dogs. Canine lymphoma can be treated, but it is rarely cured. Novel therapeutic strategies are necessary to improve outcomes in dogs diagnosed with lymphoma. Continue reading “Research Update Final 02309-T: Targeting the Cancer Epigenome: The Effect of Specific Histone Lysine Methyltransferase Inhibition in Canine B-Cell Lymphoma”
Research Update CHF 02783 EY2: Transcriptional Profiling of Canine Soft Tissue Sarcoma
Soft tissue sarcoma (STS) encompasses a number of neoplasms that are derived from mesenchymal cells including fibrosarcoma, myxosarcoma, hemangiopericytoma, and undifferentiated sarcoma. In the dog, STSs arise frequently in the dermis/subcutis and represent up to 15% of the neoplasms in this location. Our primary aim of this grant was to collect cases of canine STS for histologic and gene expression analysis. Continue reading “Research Update CHF 02783 EY2: Transcriptional Profiling of Canine Soft Tissue Sarcoma”
Research Update CHF 02534 MY 3 Update: Clinical Trial for Evaluation of Propranolol and Doxorubicin in the Treatment of Canine Hemangiosarcoma
We opened the trial on July 1, 2019. As of June 27, 2021, we have enrolled 18 dogs in the study and no dose limiting toxicities within the initial 21-day assessment period have been observed. Based on these results, we are continuing to enroll dogs at the highest dose of propranolol (1.3 mg/kg) being tested. Continue reading “Research Update CHF 02534 MY 3 Update: Clinical Trial for Evaluation of Propranolol and Doxorubicin in the Treatment of Canine Hemangiosarcoma”
Research Update CHF 02806-MOU MY2: Strategic Prevention of Canine Hemangiosarcoma: Lifetime Follow-Up
The goal of this project is to develop a reliable, accessible, and actionable test to identify dogs at risk for hemangiosarcoma during the earliest stages of the disease and to use a strategic, rationally designed approach to prevent its occurrence in these high-risk dogs before it becomes clinically detrimental and life-threatening. Continue reading “Research Update CHF 02806-MOU MY2: Strategic Prevention of Canine Hemangiosarcoma: Lifetime Follow-Up”
Research Update CHF 02751-A FINAL: Luteinizing Hormone Receptor Activation Induces Migration and Adhesion in Neoplastic Canine Lymphocytes
In the United States, spaying and neutering of dogs and cats is commonly performed to prevent the birth of unwanted pets. However, surgically removing the ovaries or testes may have unexpected consequences. Dogs that have been spayed or neutered have an increased risk for developing obesity, urinary incontinence, hypothyroidism, hyperadrenocorticism, diabetes, cruciate ligament tears, hip dysplasia, and cancer. Lymphoma is three to four times more common in spayed and neutered dogs compared to dogs left intact. In addition, dogs that are neutered before one year of age are three times more likely to develop lymphoma than dogs neutered after one year of age. This funded study is investigating the hormonal and cellular relationships between spaying/neutering and the development of lymphoma so that new treatments will be available in the future to extend life expectancies of dogs with cancer. Continue reading “Research Update CHF 02751-A FINAL: Luteinizing Hormone Receptor Activation Induces Migration and Adhesion in Neoplastic Canine Lymphocytes”
Research Update CHF 02783 EY1: Transcriptional Profiling of Canine Soft Tissue Sarcoma
Soft tissue sarcoma (STS) encompasses a number of neoplasms that are derived from mesenchymal cells including fibrosarcoma, myxosarcoma, hemangiopericytoma, and undifferentiated sarcoma. In the dog, STSs arise frequently in the dermis/subcutis and represent up to 15% of the neoplasms in this location. Our primary aim of this grant was to collect cases of canine STS for histologic and gene expression analysis. Continue reading “Research Update CHF 02783 EY1: Transcriptional Profiling of Canine Soft Tissue Sarcoma”