Research Update CHF 03169 MY1: Characterization of hookworm resistance in dogs with a novel diagnostic test for early intervention

The dog hookworm, Ancylostoma caninum, is the most common worm parasite of dogs in the United States. It is specific to dogs but can infect humans by entering through intact skin (zoonotic), causing cutaneous larval migrans, a painful skin condition. Treatment options in dogs include the benzimidazole (BZ) drugs. However, hookworms have recently developed resistance to BZs. This resistance has been associated with two mutations – F167Y and Q134H in a gene of the worm. We have developed a PCR to test for these two mutations in the feces of infected dogs. The PCR test tells us if the mutations causing resistance is present in the sample or not, and also at what level the mutation is present. We have currently tested the PCR on the feces of 75 dogs from the mid-western United States. Continue reading “Research Update CHF 03169 MY1: Characterization of hookworm resistance in dogs with a novel diagnostic test for early intervention”