Determining Risk Factors for Lymphoma

To determine whether dogs with genetic defects in an important detoxification enzyme, called GSTT, are more likely to develop lymphoma.

Lymphoma, one of the most common cancers in dogs, is fatal in most patients. Though the underlying causes of the disease aren’t understood, exposure to industrial pollutants and commonly used herbicides may increase a dog’s risk of lymphoma. Research shows that humans exposed to environmental chemicals have a higher risk for developing lymphoma, and genetic defects in the enzymes that remove environmental chemicals from the body increase this risk.

This study will determine whether dogs with genetic defects in an important detoxification enzyme, called GSTT, are more likely to develop lymphoma. The results will provide insight into the genetic and environmental risk factors for lymphoma in dogs.

Co-sponsored with the Morris Animal Foundation, Grant Number: D09CA-029

RESEARCHERS

Lauren A. Trepanier, DVM, PhD
University of Wisconsin