Discovery of public tumorspecific neoantigens (pTSNAs) and pTSNAreactive T cells arisen from hotspot mutations in canine hemangiosarcoma
Researchers will build on their discovery of “hotspot” mutations (tumor mutations shared between patients with the same cancer) to see if they can identify public tumor-specific neoantigens (pTSNAs) that are thought to play a role in immune response to cancer. Researchers hope findings will be a step toward a new immunotherapy that can be used in many different dogs suffering from hemangiosarcoma.
Co-sponsored with the Morris Animal Foundation, Grant Number: D24CA-536
Shaying Zhao, PhD, University of Georgia