Gene Expression Profiling of Relapsed Lymphoma in Dogs

Lymphoma is one of the most common cancers in dogs. Breeds with a high incidence include Boxers, Golden Retrievers, and German Shepherds. It is also one of the most treatable cancers – more than 90 percent of dogs treated with chemotherapy go into remission. Unfortunately, most dogs relapse and eventually die from the disease.

Results

The investigators compared gene-expression patterns of tumors before and after chemotherapy to determine changes that took place in the dogs that relapsed. They identified important candidate genes and different subtypes of lymphoma that will help in the development of new cancer treatments. These candidate genes must now be independently validated in another set of patient samples but have already contributed greatly to the understanding of genes associated with relapse and potential new therapeutic targets.

Co-sponsored with the Morris Animal Foundation, Grant Number: D03CA-132

RESEARCHERS

W. C. Kisseberth, DVM, PhD
Dip. ACVIM (Oncology)
Ohio State University