Identification of Bartonella henselae Immunodominant Epitopes for Diagnosis and Prevention of Canine Bartonelloses

Bartonella species are associated with severe diseases in dogs, including endocarditis, myocarditis, hepatitis, lymphadenitis, hemangiosarcoma, vasculitis, arthritis, uveitis,  meningitis, and others.

Despite diagnostic advances, current tests lack sensitivity. Bartonella infections pose a serious threat to dogs and public health due to potential transmission to humans. This study will identify Bartonella henselae B-cell and T-cell epitopes (parts of proteins recognized by the immune system) using immunoproteomic approaches. The results  will help develop a reliable ELISA diagnostic test and provide insights into proteins  that should be targeted in future vaccines to prevent Bartonella infection in dogs.

Relevance to PWDs: As with the companion Bartonella study, improved diagnostics  and potential preventive measures would benefit all breeds, especially those involved  in outdoor sports and activities.

Co-sponsored with the AKC Canine Health Foundation, Grant Number: 03337

RESEARCHERS

Edward Breitschwerdt, DVM, DACVIM; North Carolina State University

Amount: $5,000