MicroRNA Expression Profiling of Canine Osteosarcoma

By studying miRNA expression in osteosarcoma, the investigators hope to identify new molecular targets for therapy that will lead to better treatment of this disease.

Osteosarcoma, commonly known as bone cancer, is a significant cause of death in large- and giant-breed dogs. Because cancer is believed to be fundamentally a genetic disease, genomic approaches are needed to study canine bone cancer. Recently, scientists have determined that microRNAs (miRNAs), small non-protein-coding molecules, play an important role in a variety of human cancers. Using a custom microarray technology, which the investigators have developed in their laboratories, this study will identify miRNAs that are expressed in canine osteosarcoma. Researchers will then identify which miRNAs are expressed in osteosarcoma and which are associated with certain breeds and prognoses. By studying miRNA expression in osteosarcoma, the investigators hope to identify new molecular targets for therapy that will lead to better treatment of this disease.

Co-sponsored with the Morris Animal Foundation, Grant Number: D07CA-034

RESEARCHERS

W. C. Kisseberth
DVM, PhD, Dip. ACVIM (Oncology)
Ohio State University

Dr. Kisseberth is an assistant professor at Ohio State University. He received his DVM from the University of Illinois-Urbana and his Ph.D. and veterinary medical oncology residency training at the University of Wisconsin-Madison.