Developing a New Tool to Study Viral Infections and Cancer in Dogs
Development of an MHC Class I Tetramer to Study Virus- and Tumor-specific CD8+ T-cell Responses in Dogs
Summary: Researchers will develop a state-of-the-art molecular tool to track and study killer T-cell populations that are responsible for fighting viral infections and cancer in dogs.
Description: In humans, a powerful immunologic reagent called a tetramer is standardly used to visualize changes in the body’s killer T-cells. These cells respond to immunologic challenges and are critical to the body’s immune system.
Current knowledge of T-cell behavior in dogs could be significantly advanced with the development of a dog-specific tetramer. Researchers will work to construct the first canine tetramer, which would then be used in the development of vaccines for infectious diseases and cancer in dogs.
Co-sponsored with the Morris Animal Foundation, Grant Number: D15CA-015
Dr. Paul R. Hess
North Carolina State University