Research

Previously funded studies appear chronologically, with the most recent appearing first.

  • Making Advanced Discoveries in Golden Cancers

    2011
    The three-year project will examine genetic traits that contribute to risk and progression of hemangiosarcoma and lymphoma. Golden Retrievers have been one of the most popular breeds in America for decades, but unfortunately these dogs also have one of the highest incidences of cancer. Hemangiosarcoma and lymphoma account for more than 30 percent of the […]
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  • Evaluating Drugs to Treat Hemangiosarcoma

    2011
    Tyrosine kinase inhibitors may have the potential to control the growth of hemangiosarcoma. Hemangiosarcoma remains one of the deadliest canine cancers. Despite treatments such as chemotherapy, immunotherapy and surgery, dogs rarely live beyond six months after diagnosis. New approaches are needed to improve the survival time of dogs afflicted with this devastating disease. This study […]
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  • Reciprocal Relationship of PTEN and p21 in Canine Cancer

    2007
    An estimated one out of every two dogs alive today will get cancer in its lifetime, and as many as 50 percent of those will die from the disease. Despite significant gains in cancer treatment, a thorough understanding of why cancers arise and why they behave as they do is essential to improving prevention and […]
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  • Mapping Genes Associated with Canine Hemangiosarcoma

    2006
    Hemangiosarcoma (HSA), a malignant tumor of vascular endothelial cells, is a significant health concern in dogs, with an incidence of ~2% of all tumors. A national health survey of Golden Retriever reported that neoplasia accounted for >60% of all reported deaths and HAS was the most common malignant tumor affecting >15% of Golden Retrievers. A […]
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  • Canine Hemangiosarcoma

    2005
    The main goal of this project was to develop a diagnostic test that can be used to detect hemangiosarcoma cells in blood samples from dogs. The rationale for the test is based on the fact that, as a tumor of cells that line blood vessels, hemangiosarcoma tumor cells are in intimate contact with blood and […]
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  • Receptor Tyrosine Kinase Activity in Canine Hemangiosarcoma

    2004
    Hemangiosarcoma (HSA) is a common and fatal canine cancer, for which there are no effective treatments. HSA is caused by malignant blood vessel cells that spread. Despite surgery and chemotherapy, the median survival time for dogs diagnosed with HSA is little more than six months. It is more commonly seen in male dogs between eight […]
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