Research

Previously funded studies appear chronologically, with the most recent appearing first.

  • The Role of Complex Translocations Associated with TP53 Somatic Mutations for Aiding Prognosis of Canine Diffuse Large B cell Lymphoma

    2016
    Lymphoma accounts for up to 24% of all cancers diagnosed in pet dogs. Among these cases diffuse large B-cell lymphoma (DLBCL) is the most common subtype. Despite continued advances in veterinary medicine, the response to treatment for canine lymphoma remains highly variable with no reliable means to predict response. Studies of lymphoma in people have […]
    Continue reading

  • Disease Risks Associated with Spay and Neuter: A Breed-Specific, Gender Specific

    2017
    This study extends the investigator’s recently completed AKC Canine Health Foundation-funded project studying 12 dog breeds to identify major differences in the degree to which spay or neuter may be related to an increase in joint disorders (hip dysplasia; cranial cruciate ligament tear) and/or cancers (lymphoma; hemangiosarcoma; and mast cell tumor). The original breeds studied […]
    Continue reading

  • Veterinary Oncology Fellowship-University of Missouri

    2016
    Shirley Chu, DVM; University of Missouri Dr. Chu of the University of Missouri College of Veterinary Medicine is a veterinary oncology resident and graduate student pursuing her PhD. Dr. Jeffrey Bryan serves as Dr. Chu’s mentor for her project on “Examination of the Methylome of Golden Retriever B cell lymphoma”. Project Abstract: Lymphoma is one […]
    Continue reading

  • Capturing Tumor Cells in Canine Blood

    2016
    This pilot study’s aim is to develop a blood assay to count tumor cells circulating in a dog’s blood. This technique has proven effective in telling the clinician how aggressive a cancer is and provide information as to treatment and outcome for the patient. This assay is available for humans but currently not for our […]
    Continue reading

  • A Novel Approach for Prevention of Canine Hemangiosarcoma

    2016
    Hemangiosarcoma, an aggressive form of cancer in dogs, is the cause of death for one out of every five Golden Retrievers in the United States. Portuguese Water Dogs and Boxers also have an especially high risk for this disease which is devastating for all dogs. Hemangiosarcoma is incurable partly because the cancer is detected at […]
    Continue reading

  • Measuring Chemotherapy Drug Resistance in Dogs with T-cell Lymphoma

    2016
    Quantitative Assessment of Minimal Residual Disease Kinetics during CHOP Chemotherapy of Canine T-cell Lymphoma via Next-Generation TCRVß Sequencing Human cancer treatment is becoming more and more tailored to each individual case and tumor characteristics. This study will be conducted by researchers at North Carolina State University and will follow a small number of cells that […]
    Continue reading

  • Discovery of Biomarkers to Detect Lymphoma Risk, Classify For Treatment, and Predict Outcome in Goldens

    2015
    Lymphoma is a predominant cancer affecting Portuguese Water Dogs as well as numerous other breeds of dogs. Epigenetics is one growing area of research into the behavior of cancer in both medicine and veterinary medicine. One significant area of epigenetic research involves the investigation of changes to the genome that do not involve a change […]
    Continue reading

  • Health Implications of Early Spay/Neuter on Canine Health

    2015
    Most dogs in the United States are spayed or neutered, and the default recommendation has been to perform these elective surgeries prior to physical maturity. However, recent data suggest that early spay and neuter may adversely impact the health and well-being of dogs. In preliminary studies funded by CHF, Dr. Ben Hart of the UC […]
    Continue reading

  • Developing a New Tool to Study Viral Infections and Cancer in Dogs

    2015
    Development of an MHC Class I Tetramer to Study Virus- and Tumor-specific CD8+ T-cell Responses in Dogs Summary: Researchers will develop a state-of-the-art molecular tool to track and study killer T-cell populations that are responsible for fighting viral infections and cancer in dogs. Description: In humans, a powerful immunologic reagent called a tetramer is standardly […]
    Continue reading

  • Innovations in Prevention, Diagnosis, and Treatment of Cancer

    2015
    Lymphoma and hemangiosarcoma are major health problems in Portuguese Water Dogs. This study collaborates with several top universities and researchers who are utilizing cutting edge technology to identify several regions of the genome that contain genetic, heritable, risk factors for lymphoma and hemangiosarcoma in Golden Retrievers. This information can then be applied to other breeds, […]
    Continue reading