Research

Previously funded studies appear chronologically, with the most recent appearing first.

  • Determining Risk Factors for Lymphoma

    2011
    To determine whether dogs with genetic defects in an important detoxification enzyme, called GSTT, are more likely to develop lymphoma. Lymphoma, one of the most common cancers in dogs, is fatal in most patients. Though the underlying causes of the disease aren’t understood, exposure to industrial pollutants and commonly used herbicides may increase a dog’s […]
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  • Evaluating Drugs to Treat Hemangiosarcoma

    2011
    Tyrosine kinase inhibitors may have the potential to control the growth of hemangiosarcoma. Hemangiosarcoma remains one of the deadliest canine cancers. Despite treatments such as chemotherapy, immunotherapy and surgery, dogs rarely live beyond six months after diagnosis. New approaches are needed to improve the survival time of dogs afflicted with this devastating disease. This study […]
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  • MicroRNA Profiling and MicroRNA-Based Treatment of Canine Cancers

    2008
    The goals of this study are to identify important canine miRNAs that can be used to improve cancer diagnosis and treatment in the dog. Results MicroRNAs (miRNAs) are small non-protein coding RNAs that have been implicated in humans as having a fundamental role in cancer initiation and progression. Osteosarcoma (OSA) is the most common bone […]
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  • MicroRNA Expression Profiling of Canine Osteosarcoma

    2008
    By studying miRNA expression in osteosarcoma, the investigators hope to identify new molecular targets for therapy that will lead to better treatment of this disease. Osteosarcoma, commonly known as bone cancer, is a significant cause of death in large- and giant-breed dogs. Because cancer is believed to be fundamentally a genetic disease, genomic approaches are […]
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  • Reciprocal Relationship of PTEN and p21 in Canine Cancer

    2007
    An estimated one out of every two dogs alive today will get cancer in its lifetime, and as many as 50 percent of those will die from the disease. Despite significant gains in cancer treatment, a thorough understanding of why cancers arise and why they behave as they do is essential to improving prevention and […]
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  • Enhance Detection, Diagnosis and Treatment of Canine Lymphoma

    2007
    A Collaborative Study by Veterinary Oncologists, Pathologists, and Diagnostic Laboratories to Enhance Detection, Diagnosis and Treatment of Canine Lymphoma To enhance detection, diagnosis and treatment of lymphoma. Therefore altering cost of treatment according to the type of tumor (as in humans) and increase survival rate. Results Canine lymphoma is the neoplasm most often treated by […]
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  • Mapping Genes Associated with Canine Hemangiosarcoma

    2006
    Hemangiosarcoma (HSA), a malignant tumor of vascular endothelial cells, is a significant health concern in dogs, with an incidence of ~2% of all tumors. A national health survey of Golden Retriever reported that neoplasia accounted for >60% of all reported deaths and HAS was the most common malignant tumor affecting >15% of Golden Retrievers. A […]
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  • Canine Lymphoma

    2005
    MicroRNAs (miRNAs) are small non-coding RNAs that have been implicated in humans as having a fundamental role in cancer initiation and progression. Canine diffuse large B cell lymphoma (DLBCL) represents one of the most frequently encountered canine neoplasms. We hypothesized that canine DLBCL possess a unique miRNA expression signature and that miRNA dysregulation contributes to […]
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  • Canine Hemangiosarcoma

    2005
    The main goal of this project was to develop a diagnostic test that can be used to detect hemangiosarcoma cells in blood samples from dogs. The rationale for the test is based on the fact that, as a tumor of cells that line blood vessels, hemangiosarcoma tumor cells are in intimate contact with blood and […]
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  • Gene Expression Profiling of Relapsed Lymphoma in Dogs

    2004
    Lymphoma is one of the most common cancers in dogs. Breeds with a high incidence include Boxers, Golden Retrievers, and German Shepherds. It is also one of the most treatable cancers – more than 90 percent of dogs treated with chemotherapy go into remission. Unfortunately, most dogs relapse and eventually die from the disease. Results […]
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