Research Update CHF 02624 Final: Embracing Polygenicity of Common Complex Disease in Dogs: Genome-wide Association of Cruciate Ligament Rupture

We have now completed recruitment and marker genotyping of Labrador Retriever dogs under this award. A final single nucleotide polymorphism (SNP) marker data set of 1,006 dogs has been assembled and filtered for data analysis, slightly exceeding what was promised under the award. We have now completed analysis of these data to estimate heritability of cruciate ligament rupture, determined the extent of the polygenicity of the disease, and developed a genetic testing method for accurately predicting risk of cruciate ligament rupture.

Heritability of cruciate ligament rupture in the Labrador Retriever is estimated to be 0.62, a high value. The University of Wisconsin-Madison now offers risk-based genetic testing for cruciate ligament rupture in the Labrador Retriever. In our initial analysis, the accuracy of genetic testing for risk of cruciate ligament rupture in the large reference population is very accurate. We are extremely grateful for the outstanding engagement with this
project by the community of Labrador Retriever owners and breeders that we work with.

Final Research Update Dr. Muir for polygenicity of cruciate rupture.