Research Update CHF 02624 EY2: Embracing Polygenicity of Common Complex Disease in Dogs: Genome-wide Association of Cruciate Ligament Rupture

We have met our Labrador Retriever recruitment for this study over the past six months. We will continue to complete DNA isolation and marker genotyping of the remaining dogs needed for the study as long as the genotyping service remains open under the Covid-19 pandemic. Public engagement with the project continues to be good.

Over the next 6 months, we will focus on finalizing the marker data set for the study for which we do not yet have SNP genotypes. We will then undertake the computing needed to robustly estimate the heritability of cruciate ligament rupture in the Labrador Retriever and further advance prediction of risk of disease using the genomic marker data.

Our final data set is expected to include more than 1,000 Labrador Retriever dogs as promised under the award. We are extremely grateful for the outstanding engagement with this project by the community of Labrador Retriever owners and breeders that we work with.

End-Year-2 Research Update Dr. Muir for polygenicity of cruciate rupture.

Research Update CHF 02624 MY2: Embracing Polygenicity of Common Complex Disease in Dogs: Genome-wide Association of Cruciate Ligament Rupture

We have met our recruitment trajectory for this study over the past six months. We will continue to work hard to recruit additional dogs over the coming months and genotype the remaining dogs needed for the study as long as the genotyping service remains open under the Covid-19 pandemic. Public engagement with the project continues to be good. Continue reading “Research Update CHF 02624 MY2: Embracing Polygenicity of Common Complex Disease in Dogs: Genome-wide Association of Cruciate Ligament Rupture”

Research Update CHF-02107 Mid-Year: Landmark Clinical Trial to Establish the Evidence-Based Use of Regenerative Medicine to Treat Tendon Injury in Dogs

Tendon injury is common, often progresses undiagnosed, and results in reduced function, lameness and pain in both companion dogs and canine athletes. Failed healing and recurrence frequently occur because unassisted tendon healing results in scar formation with inferior mechanical properties.

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Research Update Mid-yr 1 CHF 02624: Embracing Polygenicity of Common Complex Disease in Dogs: Genome-wide Association of Cruciate Ligament Rupture

Cruciate ligament rupture (CR) is a common disabling, degenerative condition of the knee. It places a large financial burden on the American public. Inflammation of the stifle and fraying of cruciate ligament fibers, particularly in the cranial cruciate ligament, eventually leads to ligament rupture with associated stifle instability in affected dogs. CR is a moderately heritable, complex disease with genetic and environmental risk.

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Update End-Year 2 (Final)- Health Implication of Early Spay Neuter

Summary: Final update on findings at the end-year 2 in a study to develop a generalized understanding of the impact of early spay and neuter on disease risk in dogs. The goal of this project was to evaluate, using one consistent and uniform database at their large veterinary medical center (UC Davis). This update provides conclusions for several medium-to-large breed dogs regarding the impact of early spay/neuter on cancer and musculoskeletal risks. Several additional breeds were evaluated since last update. Additionally, several small breeds were evaluated determining negligible risk with early spay/neuter. Findings indicate risk vary from breed to breed.

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Update Mid-Year 2- Health Implication of Early Spay Neuter

Update on findings at the mid-year 2 in a study to develop a  generalized understanding of the impact of early spay and neuter on disease risk in dogs. The goal of this project is to evaluate, using one consistent and uniform database at their large veterinary medical center (UC Davis). This update provides conclusions for several medium-to-large breed dogs regarding the impact of early spay/neuter on cancer and musculoskeletal risks. Additionally, several small breeds were evaluated determining negligible risk with early spay/neuter.Findings indicate risk vary from breed to breed.
Continue reading “Update Mid-Year 2- Health Implication of Early Spay Neuter”