Research Update End Year 1 CHF-02428: Identifying the Disease-Defining Autoantibodies in Canine Addison’s Disease

Research update from year 1 of Dr. Friedenberg’s work with Addison’s Disease.

During the first year of this project, we focused our efforts primarily on sample collection across our three target breeds (Standard Poodles, Portuguese Water Dogs, English Cocker Spaniels). We have collected nearly all the required control samples from Standard Poodles and Portuguese Water Dogs. We have also collected the majority of the newly diagnosed and older, affected Standard Poodles and Portuguese Water dogs required.

Currently, we are focusing our efforts on increasing the number of English Cocker Spaniels we have enrolled in the study. We are also actively recruiting newly diagnosed patients across all three breeds through many online resources.

In addition to these sample recruitment efforts, are actively working with several core facilities at the University of Minnesota (histopathology, proteomics) to optimize the methods we will use to detect serum autoantibodies in dogs with a new diagnosis of Addison’s disease. We expect to optimize these methods over the next 2-3 months. Once this has been completed, we will begin to analyze the samples we have collected for the presence of anti-adrenocortical autoantibodies.

End-Year-1 Research Update Dr. Friedenberg for Addison’s Disease.