Over the 1.5 years of this study, we have focused primarily on sample collection and running an initial set of genetics experiments. We collected samples mostly through PWD-related channels working directly with our collaborators in the PWDF/PWDCA. Continue reading “Research Update 02945-MOU MY2: Understanding the genetic basis of Addison’s disease in Portuguese Water Dogs”
Research Update 02945-MOU EY1: Understanding the genetic basis of Addison’s disease in Portuguese Water Dogs
Over the first year of this study, we have focused primarily on sample collection. We collected samples mostly through PWD-related channels working directly with our collaborators in the PWDF/PWDCA. We also attended the PWD National Specialty in September 2021 to promote the study and collect samples, and we established a collaboration with Dr. Anita Oberbauer at UC Davis to share samples that she had already collected. Continue reading “Research Update 02945-MOU EY1: Understanding the genetic basis of Addison’s disease in Portuguese Water Dogs”
Research Update CHF 02428 EY-4: Identifying the Disease-Defining Autoantibodies in Canine Addison’s Disease
The goal of this project is to identify autoantibodies that are present in the blood of dogs who are newly diagnosed with Addison’s disease in three breeds: Standard Poodles, Portuguese Water Dogs, and English Cocker Spaniels. To accomplish these goals, we have been focusing on (1) collecting blood samples from dogs across all three target breeds, and (2) employing methods that allow us to detect these autoantibodies. Continue reading “Research Update CHF 02428 EY-4: Identifying the Disease-Defining Autoantibodies in Canine Addison’s Disease”
Research Update 02945-MOU MY1: Understanding the genetic basis of Addison’s disease in Portuguese Water Dogs
Over the first 6 months of this study, we have focused primarily on sample collection. We collected samples mostly through PWD-related channels working directly with our collaborators in the PWDF/PWDCA. We also attended the PWD National Specialty in September 2021 to promote the study and collect samples, and we established a collaboration with Dr. Anita Oberbauer at UC Davis to share samples that she had already collected. Continue reading “Research Update 02945-MOU MY1: Understanding the genetic basis of Addison’s disease in Portuguese Water Dogs”
Understanding the Genetics of Addison’s Disease in PWDs
April 18, 2021 07:00 ET — The Portuguese Water Dog Foundation is excited to kick off a new research study to investigate the genetics of Addison’s disease — specifically in PWDs! The study will be conducted by Drs. Steven Friedenberg and Leigh Anne Clark and their research team at the University of Minnesota College of Veterinary Medicine and Clemson University.
Research Update CHF 02428 EY-3: Identifying the Disease-Defining Autoantibodies in Canine Addison’s Disease
The goal of this project is to identify autoantibodies that are present in the blood of dogs who are newly diagnosed with Addison’s disease in three breeds: Standard Poodles, Portuguese Water Dogs, and English Cocker Spaniels. To accomplish these goals, we have been focusing on (1) collecting blood samples from dogs across all three target breeds, and (2) employing methods that allow us to detect these autoantibodies. Continue reading “Research Update CHF 02428 EY-3: Identifying the Disease-Defining Autoantibodies in Canine Addison’s Disease”
Research Update CHF 02488 Final: Addison’s Disease and Symmetrical Lupoid Onychodystrophy in Bearded Collies Provide Common Ground for Identifying Susceptibility Loci Underlying Canine Autoimmune Disorders
Hypoadrenocorticism or Addison’s disease (AD) consists of a life-threatening clinical condition that afflicts multiple purebred and mixed breed dogs. The condition results from autoimmune destruction of the adrenal glands leading to life-long cortisol deficiency. Similarly, another autoimmune condition causing pain and suffering to dogs is Symmetrical Lupoid Onychodystrophy (SLO). Continue reading “Research Update CHF 02488 Final: Addison’s Disease and Symmetrical Lupoid Onychodystrophy in Bearded Collies Provide Common Ground for Identifying Susceptibility Loci Underlying Canine Autoimmune Disorders”
Research Update Mid-year 3 CHF 02428: Identifying the Disease-Defining Autoantibodies in Canine Addison’s Disease
The goal of this project is to identify autoantibodies that are present in the blood of dogs who are newly diagnosed with Addison’s disease in three breeds: Standard Poodles, Portuguese Water Dogs, and English Cocker Spaniels. To accomplish these goals, we have been focusing on (1) collecting blood samples from dogs across all three target breeds, and (2) employing methods that allow us to detect these autoantibodies.
Research Update Mid-year 3 CHF 02488: Addison’s Disease and Symmetrical Lupoid Onychodystrophy in Bearded Collies Provide Common Ground for Identifying Susceptibility Loci Underlying Canine Autoimmune Disorders
Hypoadrenocorticism or Addison’s disease (AD) consists of a life-threatening clinical condition that afflicts multiple purebred and mixed breed dogs. The condition results from autoimmune destruction of the adrenal glands leading to life-long cortisol deficiency. Similarly, another autoimmune condition causing pain and suffering to dogs is Symmetrical Lupoid Onychodystrophy (SLO). For the study of AD and SLO we are investigating the Bearded Collie breed due to the relatively high prevalence of both conditions in this breed and a genomic structure favorable for identifying DNA variations.
Research Update End-year 2 CHF 02488: Addison’s Disease and Symmetrical Lupoid Onychodystrophy in Bearded Collies Provide Common Ground for Identifying Susceptibility Loci Underlying Canine Autoimmune Disorders
Hypoadrenocorticism or Addison’s disease (AD) consists of a life-threatening clinical condition that afflicts multiple purebred and mixed breed dogs. The condition results from autoimmune destruction of the adrenal glands leading to life-long cortisol deficiency.
