Research Update Mid-year 3 CHF 02428: Identifying the Disease-Defining Autoantibodies in Canine Addison’s Disease

The goal of this project is to identify autoantibodies that are present in the blood of dogs who are newly diagnosed with Addison’s disease in three breeds: Standard Poodles, Portuguese Water Dogs, and English Cocker Spaniels. To accomplish these goals, we have been focusing on (1) collecting blood samples from dogs across all three target breeds, and (2) employing methods that allow us to detect these autoantibodies.

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Research Update Mid-year 3 CHF 02488: Addison’s Disease and Symmetrical Lupoid Onychodystrophy in Bearded Collies Provide Common Ground for Identifying Susceptibility Loci Underlying Canine Autoimmune Disorders

Hypoadrenocorticism or Addison’s disease (AD) consists of a life-threatening clinical condition that afflicts multiple purebred and mixed breed dogs. The condition results from autoimmune destruction of the adrenal glands leading to life-long cortisol deficiency. Similarly, another autoimmune condition causing pain and suffering to dogs is Symmetrical Lupoid Onychodystrophy (SLO). For the study of AD and SLO we are investigating the Bearded Collie breed due to the relatively high prevalence of both conditions in this breed and a genomic structure favorable for identifying DNA variations.

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Research Update End-year 2 CHF 02428: Identifying the Disease-Defining Autoantibodies in Canine Addison’s Disease

The goal of this project is to identify autoantibodies that are present in the blood of dogs who are newly diagnosed with Addison’s disease in three breeds: Standard Poodles, Portuguese Water Dogs, and English Cocker Spaniels. To accomplish these goals, we have been focusing on (1) collecting blood samples from dogs across all three target breeds, and (2) employing methods that allow us to detect these autoantibodies.

Continue reading “Research Update End-year 2 CHF 02428: Identifying the Disease-Defining Autoantibodies in Canine Addison’s Disease”

Research Update Mid-year 2 CHF 02428: Identifying the Disease-Defining Autoantibodies in Canine Addison’s Disease

During the initial 1.5 years of this project, we focused our efforts on sample collection across our three target breeds (Standard Poodles, Portuguese Water Dogs, English Cocker Spaniels). We have collected nearly all the required samples from Standard Poodles and Portuguese Water Dogs. Currently, we are focusing our efforts on increasing the number of English Cocker Spaniels we have enrolled in the study. We are also actively recruiting newly diagnosed patients across all three breeds through many online resources.

Continue reading “Research Update Mid-year 2 CHF 02428: Identifying the Disease-Defining Autoantibodies in Canine Addison’s Disease”