PARKER FORD, PA, April 18, 2021 07:00 ET — The Portuguese Water Dog Foundation is excited to kick off a new research study to investigate the genetics of Addison’s disease — specifically in PWDs! The will be conducted by Drs. Steven Friedenberg and Leigh Anne Clark and their research team at the University of Minnesota College of Veterinary Medicine and Clemson University.
The goal of this project is to identify autoantibodies that are present in the blood of dogs who are newly diagnosed with Addison’s disease in three breeds: Standard Poodles, Portuguese Water Dogs, and English Cocker Spaniels. To accomplish these goals, we have been focusing on (1) collecting blood samples from dogs across all three target breeds, and (2) employing methods that allow us to detect these autoantibodies. Continue reading “Research Update CHF 02428 EY-3: Identifying the Disease-Defining Autoantibodies in Canine Addison’s Disease”
Hypoadrenocorticism or Addison’s disease (AD) consists of a life-threatening clinical condition that afflicts multiple purebred and mixed breed dogs. The condition results from autoimmune destruction of the adrenal glands leading to life-long cortisol deficiency. Similarly, another autoimmune condition causing pain and suffering to dogs is Symmetrical Lupoid Onychodystrophy (SLO). Continue reading “Research Update CHF 02488 Final: Addison’s Disease and Symmetrical Lupoid Onychodystrophy in Bearded Collies Provide Common Ground for Identifying Susceptibility Loci Underlying Canine Autoimmune Disorders”
The goal of this project is to identify autoantibodies that are present in the blood of dogs who are newly diagnosed with Addison’s disease in three breeds: Standard Poodles, Portuguese Water Dogs, and English Cocker Spaniels. To accomplish these goals, we have been focusing on (1) collecting blood samples from dogs across all three target breeds, and (2) employing methods that allow us to detect these autoantibodies.
Hypoadrenocorticism or Addison’s disease (AD) consists of a life-threatening clinical condition that afflicts multiple purebred and mixed breed dogs. The condition results from autoimmune destruction of the adrenal glands leading to life-long cortisol deficiency. Similarly, another autoimmune condition causing pain and suffering to dogs is Symmetrical Lupoid Onychodystrophy (SLO). For the study of AD and SLO we are investigating the Bearded Collie breed due to the relatively high prevalence of both conditions in this breed and a genomic structure favorable for identifying DNA variations.
Hypoadrenocorticism or Addison’s disease (AD) consists of a life-threatening clinical condition that afflicts multiple purebred and mixed breed dogs. The condition results from autoimmune destruction of the adrenal glands leading to life-long cortisol deficiency.
The goal of this project is to identify autoantibodies that are present in the blood of dogs who are newly diagnosed with Addison’s disease in three breeds: Standard Poodles, Portuguese Water Dogs, and English Cocker Spaniels. To accomplish these goals, we have been focusing on (1) collecting blood samples from dogs across all three target breeds, and (2) employing methods that allow us to detect these autoantibodies.
During the initial 1.5 years of this project, we focused our efforts on sample collection across our three target breeds (Standard Poodles, Portuguese Water Dogs, English Cocker Spaniels). We have collected nearly all the required samples from Standard Poodles and Portuguese Water Dogs. Currently, we are focusing our efforts on increasing the number of English Cocker Spaniels we have enrolled in the study. We are also actively recruiting newly diagnosed patients across all three breeds through many online resources.
Research update from year 1 of Dr. Friedenberg’s work with Addison’s Disease.
Research update from Dr. Oberbauer into identifying loci of gene for susceptibility to Addison’s Disease
