Research Update CHF 02624 EY3: Embracing Polygenicity of Common Complex Disease in Dogs: Genome-wide Association of Cruciate Ligament Rupture

We have now completed recruitment and marker genotyping of Labrador Retriever dogs under this award. A final single nucleotide polymorphism (SNP) marker data set of 1,006 dogs has been assembled and filtered for data analysis, slightly exceeding what was promised under the award.

We are now working on completing analysis of these data to estimate heritability of cruciate ligament rupture, determine the extent of the polygenicity of the disease, and develop a method for genetic testing for risk of cruciate ligament rupture. Heritability of cruciate ligament rupture in the Labrador Retriever is estimated to be 0.62.

In our initial analysis, the accuracy of genetic testing for risk of cruciate ligament rupture is excellent and we expect to offer genetic testing to the public soon.

We are extremely grateful for the outstanding engagement with this project by the community of Labrador Retriever owners and breeders that we work with.

End-Year-3 Research Update Dr. Muir for polygenicity of cruciate rupture.