Update on findings at the mid-year 2 in a study to develop a generalized understanding of the impact of early spay and neuter on disease risk in dogs. The goal of this project is to evaluate, using one consistent and uniform database at their large veterinary medical center (UC Davis). This update provides conclusions for several medium-to-large breed dogs regarding the impact of early spay/neuter on cancer and musculoskeletal risks. Additionally, several small breeds were evaluated determining negligible risk with early spay/neuter. Findings indicate risk vary from breed to breed.