Projects

  • Developing a Next Generation Sequencing Diagnostic Platform for Tick-Borne Diseases

    Diagnostic tests based on the detection of DNA from harmful organisms in clinical samples have revolutionized veterinary medicine in the last decades. Currently, diagnostic panels for several vector-borne organisms are available through universities and private labs in the USA and abroad. However, the vast majority of results from sick dogs

  • Identifying Cellular Mechanisms of Inflammation During Canine Tick-Borne Diseases

    Tick-borne diseases are found in all 50 states of the United States and are the most common vector-borne disease diagnosed in people in the US. The predominant disease is Lyme disease, caused by Borrelia burgdorferi and related species (sensu lato). Other important canine tick-borne diseases include those caused by Anaplasma

  • Enhanced Testing for the Diagnosis of Bartonellosis in Dogs

    Bartonellosis, a zoonotic bacterial disease of worldwide distribution, is caused by approximately 10 different Bartonella species. Bartonella are transmitted to canines and humans by ticks, fleas, lice, mites, and sand flies. Dr. Breitschwerdt’s laboratory demonstrated the first evidence for Bartonella infections in dogs in 1993. Bartonella species have been associated

  • Broad-Range Detection of Canine Tick-Borne Disease and Improved Diagnostics Using Next-Generation Sequencing

    Diagnostic tests based on the detection of DNA of infectious organisms from clinical samples have revolutionized veterinary medicine in the last decades. Currently, diagnostic panels for several tickborne organisms are available through universities and private laboratories in the USA and abroad. However, the vast majority of results from clinically ill