• Whole-genome Sequencing of non-prcd PRA in PWD

    The Portuguese Water Dog Foundation will contribute $9,400 for Whole Genome Sequencing (WGS) on 4 different dogs [2 affected, 1 carriers, and 1 homozygous normal]. Samples will be tested at the WGS platform at the University of Bern, Switzerland. Dr. Aguirre’s eye lab is part of a consortium at Bern

  • Genetic Background and the Angiogenic Phenotype in Cancer

    This project will continue the researchers’ observations on gene appearance profiles in hemangiosarcoma from Golden Retrievers to German Shepherd Dogs and Portuguese Water Dogs, and it also will define how new targeted therapies may effectively control the disease in these and other dog breeds. Results Certain dog breeds are prone

  • Mechanistic Relationship of IL-8 in Cell Proliferation and Survival of Canine Hemangiosarcoma

    Characterize the direct effects of IL-8 on HSA cells. Results The hypothesis tested in this project was that interleukin-8 (IL-8) promotes growth and survival of hemangiosarcoma cells. This hypothesis was based on our previous results showing significant enrichment of IL-8 gene expression in hemangiosarcoma cells compared to normal endothelial cells

  • Genetic Analysis of Hypoandrenocorticism in Nova Scotia Duck Tolling Retrievers

    Addison’s disease, also known as hypoadrenocorticism, is a deficiency of hormones that are produced by the adrenal glands and help regulate a dog’s metabolism, blood pressure, electrolyte balance and stress response. Though the disease is relatively uncommon in dogs, certain breeds—including Nova Scotia Duck Tolling Retrievers, Bearded Collies, Great Danes,

  • Pooled Association Mapping for Canine Hereditary Disorders

    To develop a system that will map genetic traits causing health problems. More than 450 canine genetic traits are listed on the Online Mendelian Inheritance in Animals list. These traits affect all body systems in dogs and can cause health problems ranging from mild disease susceptibility to severe illness and

  • Reciprocal Relationship of PTEN and p21 in Canine Cancer

    An estimated one out of every two dogs alive today will get cancer in its lifetime, and as many as 50 percent of those will die from the disease. Despite significant gains in cancer treatment, a thorough understanding of why cancers arise and why they behave as they do is

  • Mapping Genes Associated with Canine Hemangiosarcoma

    Hemangiosarcoma (HSA), a malignant tumor of vascular endothelial cells, is a significant health concern in dogs, with an incidence of ~2% of all tumors. A national health survey of Golden Retriever reported that neoplasia accounted for >60% of all reported deaths and HAS was the most common malignant tumor affecting

  • Identifying Genes Regulating Addison’s Disease in the Portuguese Water Dog

    Addison’s disease, or primary adrenocortical insufficiency, is characterized by destruction of the adrenal cortex, resulting in the inability to produce cortisone when stimulated with the hormone ACTH. In Portuguese Water Dogs (PWDs), this disease occurs with a frequency of 1-2 percent, and is a heritable autoimmune disease of low penetrance,

  • Mapping Refinement of Quantitative Trait Loci for Canine Hip Dysplasia

    Hip dysplasia is one of the most common inherited traits in dogs with an extremely high incidence in some large breeds. It is caused by mutations in multiple genes. In previous studies, investigators discovered the genetic markers that point to the chromosomal regions that harbor the genes that contribute to

  • Gene Expression Profiling of Relapsed Lymphoma in Dogs

    Lymphoma is one of the most common cancers in dogs. Breeds with a high incidence include Boxers, Golden Retrievers, and German Shepherds. It is also one of the most treatable cancers – more than 90 percent of dogs treated with chemotherapy go into remission. Unfortunately, most dogs relapse and eventually