• Developing a Next Generation Sequencing Diagnostic Platform for Tick-Borne Diseases

    Diagnostic tests based on the detection of DNA from harmful organisms in clinical samples have revolutionized veterinary medicine in the last decades. Currently, diagnostic panels for several vector-borne organisms are available through universities and private labs in the USA and abroad. However, the vast majority of results from sick dogs

  • Measuring Chemotherapy Drug Resistance in Dogs with T-cell Lymphoma

    Quantitative Assessment of Minimal Residual Disease Kinetics during CHOP Chemotherapy of Canine T-cell Lymphoma via Next-Generation TCRVß Sequencing Human cancer treatment is becoming more and more tailored to each individual case and tumor characteristics. This study will be conducted by researchers at North Carolina State University and will follow a

  • Filling the Gaps in the Canine Genome

    The sequencing of the genome of man’s best friend in 2005 has provided an invaluable resource to the canine research community, and has reinforced the position of the dog as an important model organism to study human physiology and disease. Unlike the human and the rodent models (the mouse and

  • Beyond the Genome: The Intersection of Genes and the Environment in Canine Cancer

    Not all genes are active at all times. DNA methylation (the addition of methyl groups to DNA) is one of several mechanisms that cells use to control gene expression. Abnormal patterns of DNA methylation have been observed in human cancer. However, methylation remains an unexplored dimension of canine disease. This

  • Genetic Background and the Angiogenic Phenotype in Cancer

    This project will continue the researchers’ observations on gene appearance profiles in hemangiosarcoma from Golden Retrievers to German Shepherd Dogs and Portuguese Water Dogs, and it also will define how new targeted therapies may effectively control the disease in these and other dog breeds. Results Certain dog breeds are prone

  • Mechanistic Relationship of IL-8 in Cell Proliferation and Survival of Canine Hemangiosarcoma

    Characterize the direct effects of IL-8 on HSA cells. Results The hypothesis tested in this project was that interleukin-8 (IL-8) promotes growth and survival of hemangiosarcoma cells. This hypothesis was based on our previous results showing significant enrichment of IL-8 gene expression in hemangiosarcoma cells compared to normal endothelial cells

  • Genetic Analysis of Hypoandrenocorticism in Nova Scotia Duck Tolling Retrievers

    Addison’s disease, also known as hypoadrenocorticism, is a deficiency of hormones that are produced by the adrenal glands and help regulate a dog’s metabolism, blood pressure, electrolyte balance and stress response. Though the disease is relatively uncommon in dogs, certain breeds—including Nova Scotia Duck Tolling Retrievers, Bearded Collies, Great Danes,

  • MicroRNA Profiling and MicroRNA-Based Treatment of Canine Cancers

    The goals of this study are to identify important canine miRNAs that can be used to improve cancer diagnosis and treatment in the dog. Results MicroRNAs (miRNAs) are small non-protein coding RNAs that have been implicated in humans as having a fundamental role in cancer initiation and progression. Osteosarcoma (OSA)

  • Pooled Association Mapping for Canine Hereditary Disorders

    To develop a system that will map genetic traits causing health problems. More than 450 canine genetic traits are listed on the Online Mendelian Inheritance in Animals list. These traits affect all body systems in dogs and can cause health problems ranging from mild disease susceptibility to severe illness and

  • Reciprocal Relationship of PTEN and p21 in Canine Cancer

    An estimated one out of every two dogs alive today will get cancer in its lifetime, and as many as 50 percent of those will die from the disease. Despite significant gains in cancer treatment, a thorough understanding of why cancers arise and why they behave as they do is