Research Update CHF 03045-A EY2: Artificial Intelligence and Machine Learning for Diagnosis of Dog Sperm Morphology

Collection of all semen samples required for the study has been completed. Samples from 62 dogs presented to the veterinary hospital at The Ohio State University have been obtained and preserved. At the University of Pennsylvania, slides were prepared, and images acquired using phase-contrast under 1000X magnification. A bank with over 11K images has been created. Continue reading “Research Update CHF 03045-A EY2: Artificial Intelligence and Machine Learning for Diagnosis of Dog Sperm Morphology”

Research Update CHF 03055 EY1: Evaluating Reproductive Diseases in vitro with a 3D Canine Endometrial Organoid Model

Three-dimensional (3D) organoid cell cultures present new opportunities to improve understanding of common reproductive pathologies in the bitch in a laboratory setting rather than using live animals for research. This is an improvement on using research dogs by:
i) addressing important welfare and ethical concerns,
ii) allowing more controlled study of cellular responses under hormonal influence and infectious agents, and
iii) permitting high-throughput evaluation of treatments performed in tandem. Continue reading “Research Update CHF 03055 EY1: Evaluating Reproductive Diseases in vitro with a 3D Canine Endometrial Organoid Model”

Research Update CHF 03055 MY1: Evaluating Reproductive Diseases in vitro with a 3D Canine Endometrial Organoid Model

Three-dimensional (3D) organoid cell cultures present new opportunities to improve understanding of common reproductive pathologies in the bitch in a laboratory setting rather than using live animals for research. This is an improvement on using research dogs by: i) addressing important welfare and ethical concerns, ii) allowing more controlled study of cellular responses due to different hormones and infectious agents, and iii) permitting high-throughput evaluation of treatments performed in tandem. This 3D reproductive organoid cell culture technology has not been attempted in canines prior to these studies. Continue reading “Research Update CHF 03055 MY1: Evaluating Reproductive Diseases in vitro with a 3D Canine Endometrial Organoid Model”

Research Update CHF 03045-A MY2: Artificial Intelligence and Machine Learning for Diagnosis of Dog Sperm Morphology

Collection of all semen samples required for the study has been completed. Samples from 62 dogs presented to the veterinary hospital at The Ohio State University have been obtained and preserved. At the University of Pennsylvania, slides were prepared, and images acquired using phase-contrast under 1000X magnification. A bank with 11,464 images has been created. Continue reading “Research Update CHF 03045-A MY2: Artificial Intelligence and Machine Learning for Diagnosis of Dog Sperm Morphology”

Research Update CHF 03045-A MY1: Artificial Intelligence and Machine Learning for Diagnosis of Dog Sperm Morphology

Collection of all semen samples required for the study has been completed. Samples from 62 dogs presented to the veterinary hospital at The Ohio State University have been preserved in formalin and shipped to the University of Pennsylvania. Acquisition of dog sperm images has started. In addition, we have started the work with our collaborators at the University of Wisconsin‐Madison to develop an algorithm to automatically identify and crop sperm using a bank of bovine sperm images. Continue reading “Research Update CHF 03045-A MY1: Artificial Intelligence and Machine Learning for Diagnosis of Dog Sperm Morphology”

Research Update CHF 02751-A FINAL: Luteinizing Hormone Receptor Activation Induces Migration and Adhesion in Neoplastic Canine Lymphocytes

In the United States, spaying and neutering of dogs and cats is commonly performed to prevent the birth of unwanted pets. However, surgically removing the ovaries or testes may have unexpected consequences. Dogs that have been spayed or neutered have an increased risk for developing obesity, urinary incontinence, hypothyroidism, hyperadrenocorticism, diabetes, cruciate ligament tears, hip dysplasia, and cancer. Lymphoma is three to four times more common in spayed and neutered dogs compared to dogs left intact. In addition, dogs that are neutered before one year of age are three times more likely to develop lymphoma than dogs neutered after one year of age. This funded study is investigating the hormonal and cellular relationships between spaying/neutering and the development of lymphoma so that new treatments will be available in the future to extend life expectancies of dogs with cancer. Continue reading “Research Update CHF 02751-A FINAL: Luteinizing Hormone Receptor Activation Induces Migration and Adhesion in Neoplastic Canine Lymphocytes”

Research Update CHF 02751-A EY1: Luteinizing Hormone Receptor Activation Induces Migration and Adhesion in Neoplastic Canine Lymphocytes

In the United States, spaying and neutering of dogs and cats is commonly performed to prevent the birth of unwanted pets. However, surgically removing the ovaries or testes may have unexpected consequences. Dogs that have been spayed or neutered have an increased risk for developing obesity, urinary incontinence, hypothyroidism, hyperadrenocorticism, diabetes, cruciate ligament tears, hip dysplasia, and cancer. Lymphoma is three to four times more common in spayed and neutered dogs compared to dogs left intact. In addition, dogs that are neutered before one year of age are three times more likely to develop lymphoma than dogs neutered after one year of age. This funded study is investigating the hormonal and cellular relationships between spaying/neutering and the development of lymphoma so that in the future new treatments will be available to extend life expectancies of dogs with cancer.

End-Year-1 Research Update Dr. Kutzler at early spay/neuter and neoplasia.

Update End Year 1 – Health Implication of Early Spay Neuter

Update on findings at the end of year 1 in a study to develop a generalized understanding of the impact of early spay and neuter on disease risk in dogs. The goal of this project is to evaluate, using one consistent and uniform database at their large veterinary medical center (UC Davis).

Continue reading “Update End Year 1 – Health Implication of Early Spay Neuter”