We gained substantial and seemingly important information relative to the aims of this study. We were able to obtain the initial set of samples on April 26, 2018 so we had a short delay in starting this study. Subsequently, the COVID epidemic and loss of research personal resulted in repeated interruptions in our research efforts. After completing all Year I study aims, we continued to work on improvements in immunohistochemistry and FISH localization of Bartonella organisms within various cell types. Continue reading “Research Update CHF 02519 Final: Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangiosarcomas Within and Between Geographic Locations”
Research Update CHF 02519 EY3: Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangiosarcomas Within and Between Geographic Locations
We are on track to accomplish all of our aims for this study. We were able to obtain the initial set of samples on April 26, 2018 so we had a short delay in starting this study. We have now completed all Year I study aims, with the exception of immunohistochemistry and FISH localization of Bartonella organisms within various cell types. Continue reading “Research Update CHF 02519 EY3: Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangiosarcomas Within and Between Geographic Locations”
Research Update Mid-year 3 CHF 02519: Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangiosarcomas Within and Between Geographic Locations
We are on track to accomplish all of our aims for this study. We were able to obtain the initial set of samples on April 26, 2018 so we had a short delay in starting this study. We have now completed all Year I study aims, with the exception of immunohistochemistry and FISH localization of Bartonella organisms within various cell types. An unanticipated complication arose that the mouse monoclonal antibody was no longer being made commercially. B. henselae specific FISH probes have been designed and validation of FISH probes are in-progress. IHC is also in- progress. All qPCR and ddPCR have been completed at this time and samples are waiting for FISH and IHC analysis.
Research Update End-year 2 CHF 02519: Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangiosarcomas Within and Between Geographic Locations
Hemangiosarcoma (HSA) accounts for the majority of canine malignant splenic tumors and occurs in many large dog breeds, including mixed breeds. A less common site of HSA localization is the heart (cardiac HSA). Risk factors for both cardiac and splenic HSA remain unclear, confounding development of preventative strategies. The investigators recently reported a high prevalence of species of the bacterial genus Bartonella in dogs with HSA from North Carolina, suggesting a potential role in the initiation and/or progression of this cancer.
Research Update Mid-Year-2 for CHF-02519: Prevelance of Bartonella Infection in Dogs with Cardiac and Splenic Hemangiosarcomas
Research update from Dr. Breitschwerdt looking at the potential role of the Tick-Borne bacterial infection, bartonella in the initiation and/or progression of hemangiosarcoma.
Research Final Update CHF 02287: Enhanced Testing for the Diagnosis of Bartonellosis in Dogs
Research Final Update from Dr. Breitschwerdt to enhance ability to diagnose Bartonellosis.
Research Update End-Year-1 for CHF-02519: Prevelance of Bartonella Infection in Dogs with Cardiac and Splenic Hemangiosarcomas
Research update from Dr. Breitschwerdt looking at the potential role of the Tick-Borne bacterial infection, bartonella in the initiation and/or progression of hemangiosarcoma.
Research Update Mid-Year 1 for Enhanced Testing for the Diagnosis of Bartonellosis in Dogs
Update on progress with Dr. Breitschwerdt’s work on improving diagnostics for Bartonella.
