Projects

  • Pathology Residency Training Program to support the Morris Animal Foundation Golden Retriever Lifetime Study

    This grant supports the advanced training of two aspiring veterinary pathologists who will assist with the analysis of tissue samples collected from dogs enrolled in Morris Animal Foundation’s Golden Retriever Lifetime Study. Highly trained investigators are vital to advancing the health and welfare of animals. Morris Animal Foundation is funding

  • Understanding the Relationship between Intestinal Bacteria and Inflammatory Bowel Disease (IBD)

    Scientific Title: Tackling the Canine Microbiome in Chronic Enteropathy: Characterizing the Functionally Significant Changes that Occur with Remission of Disease Summary: Researchers are looking at changes in gut bacteria that stimulate the immune system in dogs with inflammatory bowel disease to help identify novel ways to diagnose and treat this

  • Investigating Cancers and Exposure to Environmental Chemicals

    Scientific Title: Detoxification of Environmental Carcinogens by Glutathione-Stransferases in Dogs Summary: Researchers will find out how the dog’s body breaks down common environmental chemicals that have been linked to cancers in humans. Description: When dogs or humans are exposed to toxic chemicals in the environment, they use glutathione-S-transferase (GST) enzymes

  • Measuring Chemotherapy Drug Resistance in Dogs with T-cell Lymphoma

    Quantitative Assessment of Minimal Residual Disease Kinetics during CHOP Chemotherapy of Canine T-cell Lymphoma via Next-Generation TCRVß Sequencing Human cancer treatment is becoming more and more tailored to each individual case and tumor characteristics. This study will be conducted by researchers at North Carolina State University and will follow a

  • Developing a New Tool to Study Viral Infections and Cancer in Dogs

    Development of an MHC Class I Tetramer to Study Virus- and Tumor-specific CD8+ T-cell Responses in Dogs Summary: Researchers will develop a state-of-the-art molecular tool to track and study killer T-cell populations that are responsible for fighting viral infections and cancer in dogs. Description: In humans, a powerful immunologic reagent

  • Exploring New Medical Treatments for Cushing’s Syndrome in Dogs

    Novel Medical Approach to Canine Hyperadrenocorticism with Melanocortin 2 Receptor (MC2R) Antagonist and Steroidogenic Factor 1 (SF-1) Inverse Agonists Summary: Researchers will investigate potential new medical treatments for canine Cushing’s syndrome. Description: Cushing’s syndrome is a hormonal disorder that occurs when the body produces higher than normal levels of the

  • Testing a Potential Therapeutic Target for Lymphoma

    Valosin-Containing Protein (VCP): A Novel Therapeutic Target for Canine Lymphoma Summary: This study investigates a new therapeutic target (valosin-containing protein) for dogs with lymphoma. Description: A cure for canine lymphoma remains elusive, in part because of the lack of molecular-targeted therapies that can circumvent chemotherapy resistance. The research team’s previous

  • Testing Strategies to Treat Drug-Resistant Hemangiosarcomas

    Lysosomal Drug Sequestration by CSF-1R (High) Tumor Cells Contributes to Drug Resistance in Canine Hemangiosarcoma Summary: Investigators are assessing the potential for a specific tumor-cell population in canine hemangiosarcoma to sequester drugs within their lysosomes as a novel mechanism of drug resistance. Description: Canine hemangiosarcoma is a common and highly

  • Exploring the use of a Virus Based Anticancer Strategy for Lymphoma

    A Clinical Trial of VSV-cIFNbeta-NIS Oncolytic Virotherapy for Canine B-Cell Lymphoma Summary: This study explores the safety and effectiveness of a new virus-based therapy, developed at Mayo Clinic, for dogs with B-cell lymphoma. Description: Lymphoma is one of the most commonly occurring malignant tumors in dogs. Though treatable, the disease

  • Developing Ways to Improve Cancer Treatments

    Methods of predicting tumor response to a given chemotherapy protocol have historically focused on a few traits that could be measured in biopsy samples. Recent approaches have looked at the activity of genes within tumors to predict a tumor’s sensitivity to a given drug. Because many dogs with osteosarcoma eventually